Thrombopoietin mimetics

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S310000, C514S404000

Reexamination Certificate

active

10451300

ABSTRACT:
Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.

REFERENCES:
patent: 5376451 (1994-12-01), Albin et al.
patent: 6552008 (2003-04-01), Duffy et al.
patent: 6720345 (2004-04-01), Luengo et al.
patent: 286580 (1991-01-01), None
patent: 290184 (1991-05-01), None
patent: 433526 (1991-06-01), None
patent: WO 99/11262 (1999-03-01), None
patent: WO 00/28987 (2000-05-01), None
patent: WO 01/34585 (2001-05-01), None
(“Arylhydrozones and Phenylsemicarbazones of 2-aminobenzophenones as Antithrombotic agents”, Andronati et al., Pharmazie, abstract, 1995, 50(9), 632-3.
“Synthesis and Biological Evaluation of a New Series of Potential Beta Blockers with Dual Pharmacological Actions”, Viswanathan et al., Indian Drugs, abstact, 1990, 27(1), 513-15.

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