Thromboplastin extract, reagent, and preparation thereof

Details Thromboplastin extract, reagent, and preparation thereof Thromboplastin extract, reagent, and preparation thereof

1993-05-14

1995-02-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Nervous system

424583, 514 2, 514 21, 530839, 530851, A61K 3512, A61K 3530, A61K 3550

Patent

active

053913809

ABSTRACT:
A thromboplastin extract including an aqueous thromboplastin extract of a powdered thromboplastin source including a metal ion chelator. A thromboplastin reagent for use in blood coagulation tests, the thromboplastin reagent includes the extract and calcium ions, and may include one or more of a stabilizer and a preservative.
A process for preparing a thromboplastin extract including extracting a powdered thromboplastin source in an aqueous solution having a metal ion chelator, and separating the powder in solution into sedimented powder and supernatant thromboplastin extract. The supernatant thromboplastin extract is mixed with calcium ions, and may be mixed with one or more of a stabilizer and a preservative, to prepare thromboplastin reagent.

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patent: 4784944 (1988-11-01), Kolde
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Magerovskii et al., Vopr. Med. Khim. 34(3):34-9 (1988) Abstract CA109:51061.
Staroverov et al., USSR SU 1,428,464 Oct. 7, 1988 Abstract CA110:179507.
Tripodi et al., Thromb. Haemostasis 67(1):42-45 (1992) Abstract CA116:169539.
A. R. Hubbard et al., "Inhibition of Tissue Thrombo-plastin-Mediated Blood Coagulation", Thrombosis Research 42; 489-498, 1986.
R. Jensen et al., "Tissue Factor Pathway Inhibitor", Clinical Hemostasis Review, vol. 6, No. 6, Jun. 1992.

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