Thrombomodulin derivatives and conjugates

Details Thrombomodulin derivatives and conjugates Thrombomodulin derivatives and conjugates

2005-02-22

2010-11-16

Robinson, Hope A (Department: 1652)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S008100, C530S350000, C530S300000

Reexamination Certificate

active

07833978

ABSTRACT:
The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured blood vessels under physiologic conditions in vivo. Compositions and methods are disclosed relating to thrombomodulin derivatives and conjugates, including methods for site-specific pegylation and compositions of a truncated thrombomodulin derivative.

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