Thrombolytic proteins

Details Thrombolytic proteins Thrombolytic proteins

1997-07-10

1998-11-17

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

424 9464, 435212, 536232, C12N 964, C12N 1555, A61K 3849

Patent

active

058375180

ABSTRACT:
Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification within the 94 amino acid N-terminus, and/or at Arg-275, and/or at one or more of the N-linked glycosylation sites. Methods for making these proteins are disclosed as are therapeutic compositions containing same.

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