Thrombolytic compositions

Details Thrombolytic compositions Thrombolytic compositions

1989-12-29

1993-04-13

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 942, A61K 3754

Patent

active

052021211

ABSTRACT:
A thrombolytically active composition comprising in combination a modified tissue-type plasminogen activator (t-PA) as a major component and a normal human t-PA, Streptokinase or human urokinase as a minor component in a pharmaceutically acceptable excipient;

REFERENCES:
patent: 4935237 (1990-06-01), Higgins et al.
patent: 4963357 (1990-10-01), Bell et al.
Kalyan, J. Biol. Chem., vol. 263, No. 8, (Mar. 15, 1988), 3971-8.
Pannell et al., J. Clin. Invest., vol. 81 (Mar. 1988), 853-9.
Verstraete et al., Blood, vol. 67, No. 6 (Jun. 1986), 1529-41.
Ann Rev. Med., (1988), vol. 39, pp. 405-423, "Thrombolytic Therapy" D. Collen, et al.

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