Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1996-12-02
1999-09-14
Weber, Jon P.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 943, 435212, 435188, A61K 3854, A61K 3846, C12N 996, C12N 948
Patent
active
059519819
ABSTRACT:
This invention provides thrombolytic agents and methods for making and using thrombolytic agents. Specifically, the invention provides thrombolytic agents comprising a thrombolytic proteinase and a specific binding peptide that specifically binds at the site of blood clots and thrombi in vivo. The invention particularly provides chemically crosslinked conjugates of a thrombolytic proteinase and a plurality of specific binding peptide. Methods for producing such chemically crosslinked conjugates and methods for using such conjugates for eliminating thrombi in vivo to alleviate pathological conditions caused thereby are also provided. The preferred thrombolytic proteinase in the conjugate is fibrolase obtainable from Agkistrodon contortrix confortrix venom.
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Bush Larry R.
Markland, Jr. Francis S.
Sanchez Eladio Flores
Swenson Stephen
Diatide, Inc.
McDaniels Patricia A.
Noonan Kevin E.
Weber Jon P.
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