Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1983-06-27
1986-02-04
Shapiro, Lionel M.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435212, 435226, 514822, A61K 3754, C12N 948, C12N 964
Patent
active
045685452
ABSTRACT:
The invention discloses that the tissues of earthworms contain fibrinolytically or thrombolytically active ingredients which can be extracted and purified by a suitable sequence of extraction and purification procedures into the individual active ingredients including six novel proteases named F-O-HM-45, F-I-1-HM-54, F-I-2-HM-15, F-II-HM-64, F-III-1-HM-27 and F-III-2-HM-89. The chromatographic fractionation of the earthworm extract with an aqueous extractant gives five active fractions, the first four of which contain each one of the first mentioned four proteases and the last of which contains the last mentioned two proteases. The disclosure includes description of the suitable purification methods for the proteases as well as the physico-chemical identification data thereof. Various thrombolytic medicament forms prepared with the novel proteases as the effective ingredient are described together with the results of the clinical tests carried out by the oral administration of the novel proteases.
REFERENCES:
patent: 4390630 (1983-06-01), Sawyer
Inukai Tadahiko
Matsuura Akira
Mihara Hisashi
Sumi Hiroyuki
Amano Seiyaku Kabushiki Kaisha
Mihara Hisashi
Shapiro Lionel M.
LandOfFree
Thrombolytic agent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thrombolytic agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thrombolytic agent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2339876