Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-09-27
1995-11-14
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 28, 435 13, 435961, 435188, 436536, 436540, 436164, 436811, G01N 33535, G01N 33536, G01N 33541
Patent
active
054665825
ABSTRACT:
The present invention relates to the determination of thrombocytopenia induced by an inductor drug such as heparin. According to the invention, a sample is mixed with a complex of an antigenic substance such as platelet factor 4 (pF4) and heparin to determine if the sample contains antibodies which react with the complex. The presence of these antibodies is indicative of heparin-induced thrombocytopenia.
REFERENCES:
patent: 4543339 (1985-09-01), O'Neill
patent: 4844895 (1989-07-01), Thorbecke et al.
Sigma catalog 1989 p. 1212.
Huang et al, J. Biol Chem 257(19):11546-11550 Oct. 10, 1982.
Moore et al, Biochim Biophys Acta 379:370-384 1975.
McVey, D. S. et al "Detection of Antiplatelet Immunoglobulin in Thrombocytopenic Dogs" Veterinary Immunology and Immunopathology 22:101-111 1989.
Parsons Nancy J.
Scheiner Toni R.
Serbio
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