Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1993-06-16
1995-10-10
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
C07K 706, A61K 3808
Patent
active
054571774
ABSTRACT:
The radioligands are six amino acid peptides having iodinated tyrosine at amino acid position six, including Ala-pFPhe-hArg-Cha-hArg-Tyr(I)-NH.sub.2, which mimic the activated form of the thrombin receptor protein. Thrombin receptor radioligands of the present invention are useful for screening for thrombin receptor antagonists.
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Connolly Thomas M.
Feng Dong-Mei
Gould Robert J.
Nutt Ruth F.
Veber Daniel F.
Merck & Co. , Inc.
Parr Richard S.
Salata Carol A.
Warden Jill
Winokur Melvin
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