Thrombin receptor homolog

Details Thrombin receptor homolog Thrombin receptor homolog

1995-06-06

1997-11-11

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 2, 435 721, 435 651, 4352401, 4352402, 4352523, 43525411, C12N 1512

Patent

active

056865970

ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel thrombin receptor homolog (TRH) expressed in human liver. The present invention also provides for antisense molecules to the nucleotide sequences which encode TRH, diagnostic tests based on TRH encoding nucleic acid molecules, expression vectors for the production of purified TRH, antibodies capable of binding specifically to TRH, hybridization probes or oligonucleotides for the detection of TRH-encoding nucleotide sequences, genetically engineered host cells for the expression of TRH, and antagonists, antibodies and inhibitors with specific binding activity for the polypeptide TRH.

REFERENCES:
patent: 5256766 (1993-10-01), Coughlin et al.
patent: 5516889 (1996-05-01), Hollenberg
Vu et al. (1991) Cell 64: 1057-1068.
Rasmussen et al. (1991) FEBS 288: 123-128.
Wilcox et al., "Characterization of Thrombin Receptor Expression During Vascular Lesion Formulation," Cir. Res. 75(6):1029-1038 (Dec. 1994).
Brass et al., "Structure and Function of the Human Platelet Thrombin Receptor" J. Biol. Chem. 267(20):13795-13798 (Jul. 15, 1992).
Dennington et al., "The thrombin receptor," Clin. Exp. Pharmacol. Physiol. 21:349-358 (1994).

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