Thrombin receptor deficient transgenic mice

Details Thrombin receptor deficient transgenic mice Thrombin receptor deficient transgenic mice

1997-04-22

1999-09-21

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 21, 800 22, 435325, 435455, 435463, C12N 500, C12N 1585, C12N 1500, C12N 506

Patent

active

059556455

ABSTRACT:
A transgenic animal with alterations in an thrombin receptor gene is prepared by introduction of an altered thrombin receptor gene into a host animal. The resulting transgenic animals do not produce functional thrombin receptor molecules.

REFERENCES:
Bradley, A. (1992) Modifying the mouse: Design and desire. Bio/Technology 10:534-539, 1992.
Campbell, K.H.S. and Wilmut, I. (1997) Totipotency and multipotentiality of cultured cells: Applications and progress. Theriogenology 47:63-72, 1997.
Evans, M.J. and Kaufman, M.H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156, 1981.
Vu, T.-K.H. et al. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068, 1991.
Zijlstra et al. (1989) Germ-line transmission of a disrupted B2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435-438.

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