Thrombin peptide derivative dimers

Details Thrombin peptide derivative dimers Thrombin peptide derivative dimers

2004-12-30

2008-11-25

Carlson, Karen Cochrane (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Reexamination Certificate

active

07456250

ABSTRACT:
Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

REFERENCES:
patent: 5500412 (1996-03-01), Carney et al.
patent: 6855687 (2005-02-01), Carney et al.
patent: 6861407 (2005-03-01), Carney
patent: 6894027 (2005-05-01), Carney et al.
patent: 2004/0209819 (2004-10-01), Carney
patent: 2005/0203017 (2005-09-01), Hobson et al.
patent: WO 98/03632 (1998-01-01), None
PCT/US03/20626 search report PCT/IPEA/409.
Norfleet, A.M., et al., “Thrombin peptide TP508 accelerates closure of dermal excisions in animal tissue with surgically induced ischemia,”Wound Repair and Regeneration8(6):517-529 (2000).
Norfleet, A.M., et al., “Thrombin peptide, TP508, stimulates angiogenic responses in animal models of dermal wound healing, in chick chorioallantoic membranes, and in cultured human aortic and microvascular endothelial cells,”General Pharmacology35:249-254 (2002).
Sower, L.E., et al., “Thrombin Peptide, TP508, Induces Differential Gene Expression in Fibroblasts through a Nonproteolytic Activation Pathway,”Experimental Cell Research247:422-431 (1999).

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