Thrombin inhibitors

Details Thrombin inhibitors Thrombin inhibitors

1998-09-21

2000-07-11

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546122, A61K 314375, A61P 910, C07D47104

Patent

active

060873736

ABSTRACT:
A compound which inhibits human thrombin and which has the general structure ##STR1##

REFERENCES:
patent: 4296114 (1981-10-01), Appleton et al.
patent: 5260307 (1993-11-01), Ackermann et al.
patent: 5272158 (1993-12-01), Hartman et al.
patent: 5405854 (1995-04-01), Ackermann et al.
patent: 5459142 (1995-10-01), Tone et al.
patent: 5510369 (1996-04-01), Lumma et al.
patent: 5585385 (1996-12-01), Natsugari et al.
patent: 5602253 (1997-02-01), Antonsson et al.
Semple et al., J. Med. Chem., vol. 39 (1996), pp. 4531-4536, "Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors . . . ".
Bernstein, et al., J. Med. Chem., 37, 3313-3326 "Nonpeptidic Inhibitors of Human Leukocyte Elastase . . . ", 1994.
Temple, Carroll, Jr. and Gregory A. Rener, J. Med. Chem., "Antimitotic Agents: Ring Analogues and Derivatives of Ethyl . . . ", vol. 35, pp. 4809-4812 (1992).
Mack, Helmut et al., J. Enzyme Inhibition, "Design, Synthesis and Biological activity of Novel Rigid . . . , " vol. 9, pp. 73-86 (1995).
Edwards, Philip D. et al., J. American Chemical Soc., "Design, Syntheses, and Kinetic Evaluation of a Unique Class of Elastase Inhibitors . . . , " vol. 114, pp. 1854-1863 (1992).
Brown, Frederick J. et al., J. Med. Chem., "Design of Orally Active, Non-Peptidic Inhibitors of Human Leukocyte Elastase," vol. 37, pp. 1259-1261 (1994).

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