Thrombin inhibitor and preparation and use thereof

Details Thrombin inhibitor and preparation and use thereof Thrombin inhibitor and preparation and use thereof

1981-10-08

1983-04-05

Lieberman, Allan

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424177, 260112B, A23J 106

Patent

active

043791425

ABSTRACT:
Thrombin inhibitor comprising a glycoprotein of a molecular weight of 68,000 to 69,000 Dalton and an isoelectric point of pH 4.5, and is further characterized in that it inhibits thrombin in the presence of dextran sulfate at least twice as strongly as in the presence of heparin, differs immunologically from antithrombin III, and does not inhibit factor Xa, plasmin and trypsin.

REFERENCES:
patent: 4087415 (1978-05-01), Bick
Chem. Abs. 81: 88767m, 1974.
Rosenberg, R. D., J. Biol. Chem., vol. 248, No. 18, pp. 6490-6505, 1973.
Briginshaw, G. F. et al., Thrombosis Res., vol. 4, pp. 463-477, 1974.
Briginshaw, G. F. et al., Archives of Biochemistry and Biophysics, vol. 161, pp. 683-690, 1974.

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