Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-12-22
2000-12-05
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435243, 4353201, 435325, 530350, 536 235, C12N 1512, C12N 1563, C07K 1447
Patent
active
061565407
ABSTRACT:
There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.
REFERENCES:
Morgenstein, K. A. et al. Biochemistry 33:3432-3441 (1994).
Coughlin, P.B. et al., Identification and Purification of a Novel Serine Proteinase Inhibitor, The Journal of Biological Chemistry, 268 (13):9541-9547 (1993).
Coughlin, P.B. et al., Cloning and Molecular Characterication of a Human Intracellular Serine Protinease Inhibitor, Natl. Acad. Sci. U.S.A., 90:9417-9421 (1993).
Adams Mark D.
Cao Liang
Fuldner Rebecca A.
Rosen Craig A.
Human Genome Sciences Inc.
Mullins J. G.
Olstein Elliot M.
Saoud Christine
Ulm John
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