Thrombin composition for oral administration

Details Thrombin composition for oral administration Thrombin composition for oral administration

1991-02-27

1992-09-22

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 941, 424 943, 424 9464, 424499, 424529, 514802, 514834, A61K 37547

Patent

active

051495406

ABSTRACT:
A stable thrombin composition for oral administration having an excellent solubility is prepared with thrombin as a hemostatic ingredient, gelatin, albumin and glycine as a stabilizer and sucrose and/or sugar alcohol as a carrier. The thrombin composition is effective for the treatment of hemorrhage in the upper alimentary canal, is stable even at room temperature conditions for long periods of time, has excellent solubility and can be orally administered in a simple manner.

REFERENCES:
patent: 2433299 (1947-12-01), Seegers
patent: 2558395 (1951-06-01), Studer
patent: 3515642 (1970-06-01), Mima et al.
patent: 4297344 (1981-10-01), Schwinn et al.
patent: 4363319 (1982-12-01), Altshuler
patent: 4427650 (1984-01-01), Stroetmann
patent: 4563351 (1986-01-01), Caslavsky et al.
patent: 4696812 (1987-09-01), Silbering et al.
patent: 4923815 (1990-05-01), Tanaka et al.
Patent Abstracts of Japan, "Thrombin-Containing Medicinal Composition", Yoshiki Yatsuno, vol. 13, No. 362 (C-625), Aug. 14, 1989.

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