Thrombin-binding substance and process for its production

Details Thrombin-binding substance and process for its production Thrombin-binding substance and process for its production

1985-03-20

1987-01-20

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

424105, 424101, 530350, 530399, 530851, C07K 320, C07K 328

Patent

active

046380507

ABSTRACT:
A thrombin-binding substance derived from human tissue and having the characteristics of (a) molecular weight: 88,000.+-.20,000 in reduced condition and 71,000.+-.20,000 in unreduced condition; (b) isoelectric point: .sub.p H 4.2.+-.0.5; (c) affinity: strong for thrombin; (d) activities: capable of promoting the thrombin-catalyzed activation of protein C and prolonging clotting time; and (e) stability: stable over a .sub.p H range of 2 to 10 and stable to denaturing agents (sodium dodecylsulfate and urea) and to a pepsin treatment, is effectively useful for thrombolysis and anticoagulation.

REFERENCES:
patent: 4269825 (1981-05-01), Bohn et al.
patent: 4301064 (1981-11-01), Bohn
patent: 4379142 (1983-05-01), Port et al.
J. Biological Chemistry, 257, 859-864 (1982), Esmon et al.

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