Thrombin aerosol

Details Thrombin aerosol Thrombin aerosol

1987-08-31

1988-06-21

Swisher, Nancy A. B.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 45, 424101, A61K 914, A61K 3514, A61K 3700

Patent

active

047524669

ABSTRACT:
A process is disclosed for delivery thrombin in dry powdered form from an aerosol container by first lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer e.g. polyvinyl pyrrolidone, placing the lyophilized cake in a pressure bottle by crimping on a valve stem and top, filling liquified chlorofluoroalkane-containing aerosol propellant into the bottle, and actuating the valve to dispense in dry-finely divided powdered form a mixture of thrombin and polyvinyl pyrrolidone, which powdered thrombin is for use in controlling bleeding during surgery.

REFERENCES:
patent: 4427650 (1984-01-01), Stroetman
patent: 4427651 (1984-01-01), Stroetman

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