Thrombin-activated tissue plasminogen activators

Details Thrombin-activated tissue plasminogen activators Thrombin-activated tissue plasminogen activators

1987-05-22

1993-04-06

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435212, 4353201, 4352402, 4352523, 43525233, 435226, 536 232, C12N 961, C12N 1500, C12N 1558, C12N 1535

Patent

active

052003400

ABSTRACT:
Zymogens of proteins having fibrinolytic activity are disclosed. The proteins are cleavable by thrombin, the cleavage resulting in the stimulation of fibrinolytic activity. Suitable proteins which may be modified in accordance with the present invention include tissue plasminogen activator, urokinase, and plasminogen variants. The modified molecules are substantially clot-specific, in view of the large amounts of thrombin associated with clots in vivo.

REFERENCES:
Tate et al. Biochemistry vol. 26: 338-343 (1987).
Stryer, Biochemistry, 1981, p. 105, 2nd Edition, Freeman & Co., San Francisco, U.S.A.
Lijnen, et al., Eur. J. Biochem, vol. 169, p. 359-364, 1987.
Ichinose et al., J. Biol. Chem., vol. 261, p. 3486-3489, 1986.

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