Thrombin activatable plasminogen analogues

Details Thrombin activatable plasminogen analogues Thrombin activatable plasminogen analogues

1993-10-29

1997-11-18

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435217, 424 9464, A61K 3848, C12N 968, C12P 2100

Patent

active

056886640

ABSTRACT:
A plasminogen analogue activatable by thrombin to have plasmin activity which contains the cleavage site sequence (SEQ ID NO: 23): ##STR1## where Xaa at position 1 represents P4; Xaa at position 2 represents P3; Xaa at position 5 represents P1'; and Xaa at position 6 represents P2' where P3 is a basic amino acid residue, P4 is a hydrophobic amino acid residue and each of P1' and P2' is independently a non-acidic amino acid residue, said site being cleavable by thrombin between Arg and P1'.

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