Threonyl-valyline leucine containing peptides and pharmaceutical

Details Threonyl-valyline leucine containing peptides and pharmaceutical Threonyl-valyline leucine containing peptides and pharmaceutical

1977-02-28

1979-03-27

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

041466144

ABSTRACT:
Polypeptides, omega-N-acylated and/or hydrocarbon-containing esters or amides of polypeptides are useful in the treatment of schizophrenia. The polypeptide-containing materials have a characteristic T-V-L structure, i.e., ##STR1## The preferred compositions are N-acylated T-V-L containing polypeptides, especially amides.

REFERENCES:
patent: 3873722 (1975-03-01), Smythies
patent: 3885034 (1975-05-01), Risse et al.
patent: 3932623 (1976-01-01), Wilson
Kolb, Modern Clinical Psychiatry, pp. 311-312 (1973).
Harlow, Academy of Medicine (1960), pp. 1-41.
Beckett et al., The American Journal of Psychiatry 119, pp. 835-842 (1963).
Heath, Diseases of the Nervous System 33, pp. 157-163 (1972).
Bergen et al., Serological Fractions in Schizophrenia, p. 67 (1963).
Carey, Biological Psychiatry 8, pp. 75-88 (1974).
Caldwell et al., Biological Psychiatry 8, pp. 235-244 (1974).
Frohman et al., Molecular Basis of Some Aspects of Mental Activity 2, pp. 241-255 (1967).
Frohman, Mind as a Tissue, pp. 181-195.
Frohman et al., Recent Advances in Biological Psychiatry 7, pp. 45-51 (1964).
Frohman et al., Biological Psychiatry 7, pp. 53-61 (1973).
Harmison et al., Biochemistry 21, pp. 4485-4493.
Chemistry and Biology of Peptides, pp. 423, 427, 428, (1972).

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