Threonyl tRNA synthetase polynucleotides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 701, 435 711, 4352523, 4353201, 435325, 536 231, 536 237, C12P 2106, C12P 2104, C12N 1500, C07H 2104

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059587334

ABSTRACT:
The invention provides thrS polypeptides and DNA (RNA) encoding thrS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing thrS polypeptides to screen for antibacterial compounds.

REFERENCES:
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J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Putzer et al., "Independent Genes for Two Threonyl-tRNA Synthetasesin Bacillus subtilis,"Journal of Bacteriology, 172(8) pp. 4593-4602 (1990).
Ogasawara et al., "Nucleotide sequence and organization of dnaB gene and neighbouring genes onthe bacillus subtilis chromosome," Nucleic Acids Research, 14(24) pp. 9989-9999 (1986).
Fleischmann et al., "Whole-Genome Random Sequencing and Assemblyof Haemophilius influenzae Rd.,"Science, 269 pp. 496-512 (1995).
Lazar et al (Molecular & Cellular Biology vol. 8 No. 3, Mar. 1988 pp. 1247-1252).
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