Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or...
Reexamination Certificate
2011-08-30
2011-08-30
Canella, Karen A (Department: 1643)
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
C435S374000, C435S375000
Reexamination Certificate
active
08007991
ABSTRACT:
Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the movement of cells away from the margins of samples of target tissue through the matrix, to be evaluated in a manner that produces data useful for evaluating the oncological status and characteristics of the cells. In a further key aspect, the invention permits the in vitro testing and analysis of one or more conventional, experimental or theoretical therapies with respect to specific target tissues or cells. Among such therapies are therapeutic compounds and combinations thereof, radiation therapies, combinations of therapeutic compounds and radiation and numerous other possible therapies.
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Costello Penelope Catherine
McDonald Warren Bruce
Canella Karen A
Shaffer Gary L.
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