Three-dimensional liver cell and tissue culture system

Details Three-dimensional liver cell and tissue culture system Three-dimensional liver cell and tissue culture system

1995-05-31

1997-04-29

Rollins, John W.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

435373, 435402, 435399, 424423, C12N 500, C12M 300, A61K 200

Patent

active

056248407

ABSTRACT:
The present invention relates to a three-dimensional cell and tissue culture system. In particular, it relates to this culture system for the long term culture of liver cells and tissues in vitro in an environment that more closely approximates that found in vivo. The culture system described herein provides for proliferation and appropriate liver cell maturation to form structures analogous to tissue counterparts in vivo. The resulting liver tissues survivo for prolonged periods, perform liver-specific functions, and maintain hepatic tissue architecture following in vivo implantation. The liver cultures have a variety of applications ranging from transplantation or implantation in vivo, to screening cytotoxic compounds and pharmaceutical compounds in vitro, to the production of biologically active molecules in "bioreactors" and to the construction of extracorporeal liver assist device.

REFERENCES:
patent: 3997396 (1976-12-01), Delente
patent: 4016036 (1977-04-01), Green et al.
patent: 4024020 (1977-05-01), Weiss et al.
patent: 4087327 (1978-05-01), Feder et al.
patent: 4107937 (1978-08-01), Chmiel
patent: 4117881 (1978-10-01), Williams et al.
patent: 4135975 (1979-01-01), Lichtman et al.
patent: 4144126 (1979-03-01), Burbridge
patent: 4228243 (1980-10-01), Iizuka
patent: 4280954 (1981-07-01), Yannas
patent: 4299819 (1981-11-01), Eisinger
patent: 4342828 (1982-08-01), Takaku et al.
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4481946 (1984-11-01), Altshuler et al.
patent: 4485096 (1984-11-01), Bell
patent: 4485097 (1984-11-01), Bell
patent: 4486188 (1984-12-01), Altshuler et al.
patent: 4489710 (1984-12-01), Spitler
patent: 4520821 (1985-06-01), Schmidt et al.
patent: 4539716 (1985-09-01), Bell
patent: 4546500 (1985-10-01), Bell
patent: 4553272 (1985-11-01), Mears
patent: 4604346 (1986-08-01), Bell
patent: 4621100 (1986-11-01), Lund et al.
patent: 4642292 (1987-02-01), Reid et al.
patent: 4645669 (1987-02-01), Reid
patent: 4703108 (1987-10-01), Silver
patent: 4835102 (1989-05-01), Bell
Freshney, "Culture Of Animal Cells, A manual Of Basic Technique" 1983, Alan R. Liss, Inc. N.Y.
Lydersen, "Layer Scale Cell Culture Technology" 1987, Hansen Publishers, Munich, Vernon, New York.
Thilly, "Mammalian Cell Technology," 1986, Butterworths, Boston, London, Durban, Singapore, Sydney, Toronto, Wellington.
Old Primrose, "Principles Of Gene Manipulation". An Introduction to Genetic Engineering Chapter in Studies in Microbiology, vol. 2, Third Edition, 1985, Blackwell Scientific Publication.
PCT International Publication No. WO88/03785, by Vacanti and Langer, International Application No. PCT/US87/03091, International Publication Date Jun. 2, 1988, U. S. Priority Date Nov. 20, 1986.
Sarber, et al., 1981, Mechanisms of Aging and Development, 17:107-117.
Nusgens et al., 1984, Collagen Rel. Res. 4:351-364.
Leighton, J., 1951, J.N.C.I. 12:545-561.
Schneider, H. et al., 1963, Exp. Cell Res. 30:449-459.
Kruse, P. et al., 1965, J. Cell Biol. 27:273-279.
Leighton, J. et al., 1967, Science 155:1259-1261.
Leighton, J. et al., 1968, Cancer Res. 28:286-296.
Elsdale et al., 1972, J. Cell Biol. 54:626-637.
Ansevin, K. et al., 1973, In Vitro 8:483-488.
Sobour, O. et al., 1975, J. Neurosurg 43:742-749.
Douglas, W. H. et al, 1976, In Vitro 12:373-381.
Ebendal, E., 1976, Exp. Cell Res. 98:159-169.
Emerman, J., et al., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:4466-4470.
Bell, E., et al., 1979, PNAS 76:1274-1278.
Lindsay, R.,1979, Nature 282:80-83.
Reid, L., et al., 1979, 58:263-278.
Yang, L. et al., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:3401-3405.
Douglas, W. et al., 1980, In Vitro 16:306-312.
Folkman, J. et al., Nature 288:551-555.
Vlodavsky, D. et al., 1980, Cell 19:607-616.
Yang, J. et al., 1980, PNAS 77:2088-2092.
Yang, J. et al., 1981, Cancer Res 41:1021-1027.
Thuroff, et al., 1983, Urology 21:155-158.
Daniels, E. and Moore, 1969, Anat. Res. 163:174.
Daniels, E., 1975, Anat. Rec. 181:341.
Dexter, T. M. et al., 1976, in "Methods in Cell Biology," editor D. M. Prescott, pp. 387-405, Academic Press, N. Y.
Dexter, T. M. et al., 1976, J. Cell. Physiol. 91:335-344.
Blackburn, M. et al., 1977, Br. J. Haematology 37:337.
Dexter, T. M., 1979, Acta Haemat. 62:299-305.
Daniels, E., 1978, Anat. Rec. 190:376.
Moore, M. A. S. et al., 1979, Blood Cells 5:297-311.
Reimann, J. et al., 1979, Exp. Hematol. 7:52-58.
Daniels, E., 1980, Exp. Hematol. 8:157-165.
Gartner, S. et al., 1980, Proc. Natl. Acad. Sci. 77:4756-4759.
Hocking, W. G. et al., 1980, in "Biology of Bone Marrow Transplantation", edited by R. B. Gale, et al., pp. 431-442, Academic Press, N. Y.
Daniels, 1981, Exp. Hematol. 9:697-710.
Daniels, E., 1981, Anat. Rec. 199:63A.
Coulombel et al., 1983, Blood 62:291-297.
Daniels, E., 1983, RES: Journal of Recticuloendothelial Society 33:457-465.
Dexter, T. et al., 1984, in "Long-Term Bone Marrow" editor Wright et al., pp. 57-96, Alan R. Liss, Inc., N. Y.
Greenberger, J. S., 1984, in "Long-Term Bone Marrow Culture", editor D. Wright, pp. 119-131, Alan R. Liss, N.Y.
Sirica, A., Ricahards, W., Tsukada, Y., Sattler, C., and Pitot, H., 1979, Proc. Natl. Acad. Sci., U.S.A. 76:283-287.
Sirica, A., Hwang, C., Sattler, G. and Pitot, H., 1980, Cancer Res. 40:3259-3267.
Latsinik et al., 1981, Biol. Abstr. 74:3841.
Gordon et al., 1983, Int. J. Cell Cloning 1:429-39.
Chailakbyan et al., 1984, Biol. Abstr. vol. 80, abstract 28317.
Phillips, R.A., 1984, in "Long-Term Bone Marrow Culture", editor D. Wright, pp. 309-321, Alan R. Liss, Inc., N.Y.,
Chang, J., et al., 1986, The Lancet, pp. 294-295.
Brockbank, K.G.M., et al., 1986, Exp. Hematol. 14:386-394.
McMillen, et al., 1986, J. Surg. Res. 40:193-197.
Naughton et al., 1986, Blood 68:149a.
Page et al., 1986, Exp. Hematol. 14:719-723.
Yuen et al., 1986, Exp. Hematol. 14:771-775.
Hunt et al., 1987, Cell 48:996-1007.
Rennick et al., 1987, Blood 69:682-691.
Whitlock et al., 1987, Cell, 48:1009-1021.
E. Daniels, 1977, Anat. Rec. 187:562.
Gorin, N.C. et al., 1978, Blood 51:2157-265.
Ritz et al, 1982, The Lancet, Jul. 10, 1982, pp. 60-63.
Van De Ouweland, F. et al., 1982, Cryobiology 19:292-298.
Parkman, 1986, Science 232:1373-1378.
Green et al., 1978, Science 200:1385-1388.
Bell, E. et al., 1979, Proc. natl. Acad. Sci. U.S.A. 76:1274-1278.
Green, H. et al., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:5665-5668.
Yannas, I. et al., 1980, J. Biomedical Res. 14:107-131.
Bell, E. et al., 1981, Science 2311:1052-1054.
Yannas et al., 1982, Science 215:174-176.
Bell, E. et al, 1983, J. Invest. Dermatol. 81:2.sub.s -10.sub.s.
Kao, J. et al., 1983, Toxicol. and Appl. Pharmacol. 68:206-217 (1983).
Gallico et al., 1984, N. Engl. J. Med. 311:448-451.
Pittelkow et al., 1986, mayo Clin. Proc. 61:771-777.
Boyce, J. et al., 1988, Surgery 421-431.
Michalopoulos, G. and Pitot, H., 1975, Fed. Proc. 34:826.
Michalopoulos, G., Sattler, G., O3 Connor, L., and Savage, R. and Bonney, R., 1978, Exp. Cell Res. 114:307-315.

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