Three-dimensional kidney cell and tissue culture system

Details Three-dimensional kidney cell and tissue culture system Three-dimensional kidney cell and tissue culture system

1995-04-06

1996-05-14

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 11, 435 29, 435 32, 4352401, 4352402, 43524023, 4352841, 435 12, 424422, 424484, 424572, C12N 500, C12Q 102, A01N 102

Patent

active

055166806

ABSTRACT:
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance with the invention, cells derived from a desired tissue are inoculated and grown on a pre-established stromal support matrix. The stromal support matrix comprises stromal cells, such as fibroblasts actively growing on a three-dimensional matrix. Stromal cells may also include other cells found in loose connective tissue such as endothelial cells, macrophages/monocytes, adipocytes, pericytes, reticular cells found in bone marrow stroma, etc. The stromal matrix provides the support, growth factors, and regulatory factors necessary to sustain long-term active proliferation of cells in culture. When grown in this three-dimensional system, the proliferating cells mature and segregate properly to form components of adult tissues analogous to counterparts found in vivo.

REFERENCES:
patent: 3997396 (1976-12-01), Delente
patent: 4016036 (1977-04-01), Green et al.
patent: 4024020 (1977-05-01), Weiss et al.
patent: 4087327 (1978-05-01), Feder et al.
patent: 4107937 (1978-08-01), Chmiel
patent: 4117881 (1978-10-01), Williams et al.
patent: 4135975 (1979-01-01), Lichtman et al.
patent: 4144126 (1979-03-01), Burbridge
patent: 4228243 (1980-10-01), Iizuka
patent: 4280954 (1981-07-01), Yannas
patent: 4299819 (1981-11-01), Eisinger
patent: 4342828 (1982-08-01), Takaku et al.
patent: 4391909 (1983-07-01), Lim
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4481946 (1984-11-01), Altshuler et al.
patent: 4485096 (1984-11-01), Bell
patent: 4485097 (1984-11-01), Bell
patent: 4486188 (1984-12-01), Altshuler et al.
patent: 4489710 (1984-12-01), Spitler
patent: 4520821 (1985-06-01), Schmidt et al.
patent: 4539716 (1985-09-01), Bell
patent: 4546500 (1985-10-01), Bell
patent: 4553272 (1985-11-01), Mears
patent: 4604346 (1986-08-01), Bell
patent: 4621100 (1986-11-01), Lund et al.
patent: 4642292 (1987-02-01), Reid et al.
patent: 4645669 (1987-02-01), Reid
patent: 4703108 (1987-10-01), Silver
patent: 4835102 (1989-05-01), Bell
Leighton, J., 1951, J.N.C.I. 12:545-561.
Schneider, H. et al., 1963, Exp. Cell Res. 30:449-459.
Kruse, P. et al., 1965, J. Cell Biol. 27:273-279.
Leighton, J. et al., 1967, Science 155:1259-1261.
Leighton, J. et al., 1968, Cancer Res. 28:286-296.
Elsdale et al., 1972, J. Cell Biol. 54:626-637.
Ansevin, K. et al., 1973, In Vitro 8:483-488.
Sobour, O. et al., 1975, J. Neurosurg 43:742-749.
Douglas, W. H. et al., 1976, In Vitro 12:373-381.
Ebendal, E., 1976, Exp. Cell Res. 98:159-169.
Emerman, J., et al., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:4466-4470.
Bell, E., et al., 1979, PNAS 76:1274-1278.
Linsay, R., 1979, Nature 282:80-82.
Reid, L. et al., 1979, 58:263-278.
Yang, J. et al., 1979, Proc. Natl Acad. Sci. U.S.A. 76:3401-3405.
Douglas, W. et al., 1980, In Vitro 16:306-312.
Folkman, J. et al., 1980, Nature 288:551-555.
Vlodavsky, D. et al., 1980, Cell 19:607-616.
Yang, J. et al., 1980, PNAS 77:2088-2092.
Yang, J. et al., 1981, Cancer Res 41:1021-1027.
Thuroff, et al., 1983, Urology 21:155-158.
Daniels, E. and Moore, 1969, Anat. Res. 163:174.
Daniels, E., 1975, Anat. Rec. 181:341.
Dexter, T. M. et al., 1976, in "Methods in Cell Biology," editor D. M. Prescott, pp. 387-405, Academic Press, N.Y.
Dexter, T. M. et al., 1976, J. Cell. Physiol. 91:335-344.
Blackburn, M. et al., 1977, Br. J. Haematology 37:337.
Dexter, T. M., 1979, ActaHaemat. 62:299-305.
Daniels, F., 1978, Anat. Rec. 190:376.
Moore, M. A. S. et al, 1979, Blood Cells 5:297-311.
Reimann, J. et al., 1979, Exp. Hematol 7:52-58.
Daniels, E., 1980, Exp. Hematol. 8:157-165.
Gartner, S. et al., 1980, Proc. Natl. Acad. Sci. 77:4756-4759.
Hocking, W. G. et al., 1980, in "Biology of Bone Marrow Transplantation", edited by R. B. Gale, et al., pp. 431-442, Academic Press, N.Y.
Daniels, 1981, Exp. Hematol. 9:697-710.
Daniels, E., 1981, Anat. Rec. 199:63A.
Coulombel et al., 1983, Blood 62:291-297.
Daniels, E., 1983, RES: Journal of Recticuloendothelial Society 33:457-465.
Dexter, T. et al., 1984, in "Long-Term Bone Marrow" editor Wright et al., pp. 57-96, Alan R. Liss, Inc., N.Y.
Greenberger, J. S., 1984, in "Long-Term Bone Marrow Culture", editor D. Wright, pp. 119-131, Alan R. Liss, N.Y.
Phillips, R. A., 1984, in "Long-Term Bone Marrow Culture", editor D. Wright, pp. 309-321, Alan R. Liss, Inc., N.Y.
Chang, J., et al., 1986, The Lancet, pp. 294-295.
Brockbank, K. G. M., et al., 1986, Exp. Hematol. 14:386-394.
McMillen, et al., 1986, J. Surg. Res. 40:193-197.
Naughton et al., 1986, Blood 68:149a.
Page et al., 1986, Exp. Hematol. 14:719-723.
Yuen et al., 1986, Exp. Hematol. 14:771-775.
Hunt et al., 1987, Cell, 48:996-1007.
Rennick et al, 1987, Blood 69:682-691.
Whitlock et al., 1987, Cell, 48:1009-1021.
F. Daniels, 1977, Anat. Rec. 187:562.
Corin, N. C. et al., 1978, Blood 51:2157-265.
Ritz et al, 1982, The Lancet, Jul. 10, 1982, pp. 60-63.
Van De Ouweland, F. et al., 1982, Cryobiology 19:292-298.
Parkman, 1986, Science 232:1373-1378.
Green et al., 1978, Science 200:1385-1388.
Bell, E. et al., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:1274-1278.
Green, H. et al., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:5665-5668.
Yannas, I. et al., 1980, J. Biomedical Res. 14:107-131.
Bell, E. et al., 1981, Science 211:1052-1054.
Yannas et al., 1982, Science 215:174-176.
Bell, E. et al., 1983, J. Invest. Dermatol 81:2-10.
Kao, J. et al, 1983, Toxicol and Appl. Pharmacol. 68:206-217 (1983).
Gallico et al., 1984, N. Engl. J. Med. 311:448-451.
Pittelkow et al., 1986, Mayo Clin. Proc. 61:771-777.
Boyce, J., et al., 1988, Surgery 421-431.
Michalopoulos, G. and Pitot, H., 1975, Fed. Proc. 34:826.
Michalopoulos, G., Sattler, G., O'Connor, L., and.
Savage, R. an Bonney, R., 1978, Exp. Cell Res. 114:307-315.
Sirica, A., Ricahards, W., Tsukada, Y., Sattler, C., and Pitot, H., 1979, Proc. Natl. Acad. Sci., U.S.A. 76:283-287.
Sirica, A., Hwang, C., Sattler, G. and Pitot, H., 1980, Cancer Res. 40:3259-3267.
Latsinik et al., 1981, Biol. Abstr. 74:3841.
Gordon et al., 1983, Int. J. Cell Cloning 1:428-39.
Chailakhyan et al., 1984, Biol. Abstr. vol. 80, abstract 28317.
Sarber, et al., 1981, Mechanisms of Aging and Development, 17:107-117.
Nusgens et al., 1984, Collagen Rel. Res. 4:351-364.
Freshney, "Culture of Animal Cells, A Manual of Basic Technique" 1983, Alan R. Liss, Inc. N.Y.
Lydersen, "Layer Scale Cell Culture Technology" 1987, Hansen Publishers, Munich, Vernon, New York.
Thilly, "Mammalian Cell Technology," 1986, Butterworths, Boston, London, Durban, Singapore, Sydney, Toronto, Wellington.
Old Primrose, "Principles of Gene Manipulation. An Inroduction to Genetic Engineering `Chapter` in Studies in Microbiology", vol. 2, Third Edition, 1985, Blackwell Scientific Publication.

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