Data processing: structural design – modeling – simulation – and em – Simulating nonelectrical device or system – Biological or biochemical
Reexamination Certificate
2008-07-22
2008-07-22
Shah, Kamini S (Department: 2128)
Data processing: structural design, modeling, simulation, and em
Simulating nonelectrical device or system
Biological or biochemical
C514S012200, C514S002600, C514S121000, C514S574000, C514S089000, C424S141100, C424S093210, C424S146100, C424S078370, C600S340000, C600S416000, C600S419000, C600S159000
Reexamination Certificate
active
07403883
ABSTRACT:
An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticum of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.
REFERENCES:
patent: 2207153 (1940-07-01), Judovich
patent: 3724467 (1973-04-01), Avery et al.
patent: 4773865 (1988-09-01), Baldwin
patent: 5501703 (1996-03-01), Holsheimer et al.
patent: 5643330 (1997-07-01), Holsheimer et al.
patent: 5672059 (1997-09-01), Browne-Wilkinson
patent: 6319241 (2001-11-01), King et al.
patent: 6422874 (2002-07-01), Green et al.
patent: 6795737 (2004-09-01), Gielen et al.
patent: 6908309 (2005-06-01), Gil et al.
patent: 7218964 (2007-05-01), Hill et al.
patent: 2001/0053885 (2001-12-01), Gielen et al.
patent: 2003/0083299 (2003-05-01), Ferguson
patent: 2004/0101815 (2004-05-01), Jay et al.
patent: 2004/0203079 (2004-10-01), Pentyala
patent: 2 776 805 (1999-10-01), None
patent: 2232522 (1990-12-01), None
patent: 2 369 714 (2002-06-01), None
patent: WO 99/50808 (1999-10-01), None
“Injury of the anterior longitudinal ligament during whiplash simulation”, Ivancic et al, European Spine Journal, pp. 61-68, 2003.
Whole Cervical Spine Model with Muscle Force Replication for Whiplash Simulation: Development and Evaluation, Ivancic et al, Yale University, 2003.
“Biofidelic whole cervical spine model with muscle force replication for whiplash simulation”, Ivancic et al, European Spine Journal, 2004.
U.S. Appl. No. 60/566,866, filed Apr. 30, 2004, Heruth et al.
Di Chiro et al., “Spinal descent of cerebrospinal fluid in man,”Neurology, 1976;26:1-8.
Greitz et al., “On the Pulsatile Nature of Intracranial amd Spinal CSF-Circulation Demonstrated by MR Imaging,”Acta Radiologica, 1993;34:321-328.
Holsheimer, et al., “MR Assessment of the Normal Position of the Spinal Cord in the Spinal Canal,”Am. J. Neuroradiol., 1994;15:951-959.
Nitz et al., “Flow Dynamics of Cerebrospinal Fluid: Assessment with Phase-Contrast Velocity MR Imaging Performed with Retrospective Cardiac Gating,”Radiology, 1992:183:395-405.
Thomsen et al., “Fourier Analysis of Cerebrospinal Fluid Flow Velocities: MR Imaging Study,”Radiology, 1990;177:659-665.
Kekesi et al., “The Antinociceptive Potencies and Interactions of Endogenous Ligands During Continuous Intrathecal Administration: Adenosine, Agmatine, and Endomorphin-1,”Anesth. Analg., 2004;98(2):420-426.
Krupp et al., “Pharmacokinetics of Intrathecal Oligodeoxynucleotides,”Anesthesiology, 2004;100(2):315-322.
Rigler et al., “Distribution of Catheter-injected Local Anesthetic in a Model of the Subarachnoid Space,”Anesthesiology, 1991;75:684-692.
Yaksh, Ed.,Spinal Drug Delivery, Elsevier Science B.V., Amsterdam, The Netherlands, 1999; cover page, title page, introductory pages, table of contents, and pp. 1-614.
Wall et al.,Textbook of Pain, Fourth Edition, Churchill Livingstone, London, 1999; title page, copyright page, and table of contents, 5 pages.
De Wachter et al., “Distribution of Marcaine® in an in vitro model of the subarachnoid space conforming to actual spinal column geometries,”Technology and Health Care, 1997;5:437-447.
Hegland Michael
Heruth Kenneth T.
Lent Mark S.
Luu Cuong V
Medtronic Inc.
Mueting Raasch & Gebhardt, P.A.
Shah Kamini S
LandOfFree
Three-dimensional in-vitro spinal models and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Three-dimensional in-vitro spinal models and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Three-dimensional in-vitro spinal models and methods of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2763590