Three-dimensional hydrogel/cell system

Details Three-dimensional hydrogel/cell system Three-dimensional hydrogel/cell system

2005-03-29

2005-03-29

Kaushal, Sumesh (Department: 1636)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S422000, C424S423000, C424S489000, C435S174000, C435S177000, C435S182000, C435S382000, C523S113000, C623S023760

Reexamination Certificate

active

06872387

ABSTRACT:
Methods and compositions are described that provide scaffolds for the support of cells. The scaffolds of the present invention have structural uniformity and desirable mechanical properties that make them suitable for a variety of uses, including uses for in vitro tissue regeneration or in vivo tissue or organ replacement. A method is described for controlling three-dimensional structure of the hydrogel/cell constructs under tissue culture environment.

REFERENCES:
patent: 5514378 (1996-05-01), Mikos et al.
patent: 5658329 (1997-08-01), Purkait et al.
patent: 5658343 (1997-08-01), Hauselmann et al.
patent: 5709854 (1998-01-01), Griffith-Cima et al.
patent: 5716404 (1998-02-01), Vacanti et al.
patent: 5801033 (1998-09-01), Hubbell et al.
patent: 5834001 (1998-11-01), Dionne et al.
patent: 5853717 (1998-12-01), Schinstine et al.
patent: 5855610 (1999-01-01), Vacanti et al.
patent: 5855613 (1999-01-01), Antanavich et al.
patent: 5858747 (1999-01-01), Schinstine et al.
Catherine K. Kuo et al, Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties, Biomaterials 22 (2001) 511-521.*
Xingwu Wang et al, Calcium alginate gels: formation and stability in the presence of an inert electrolyte, Polymer vol. 39, No. 13, pp. 2759-2764, 1998.*
A. Martinsen et al, Alginate as Immobilization Material: I. Correlation between Chemical and Physical Properties of Alginate Gel Beads, Biotechnology and Bioengineering, vol. 33, pp. 79-89, 1989.*
Cao et al. Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, Mar. 1996.*
Draget et al, Carbohydrate Polymer 14: 159-178, 1991.*
P.X. Ma and R. Langer, “Fabrication of biodegradable polymer foams for cell transplantation and tissue engineering”, vol. 18:Tissue Engineering Methods and Protocols,M. Yarmush and J. Morgan, Editors. 1998, Humana Press Inc.: Totowa, NJ.
P.X. Ma, B. Schloo, D. Mooney, and R. Langer, “Development of biomechanical properties and morphogenesis of in vitro tissue engineered cartilage”,J Biomed Mater Res,29(12): 1587-1595 (1995).
P.X. Ma and R. Langer, “Degradation, structure and properties of fibrous nonwoven poly(glycolic acid) scaffolds for tissue engineering”,Mat. Res. Soc. Symp. Proc.vol. 394, Pittsburgh, 99-104 (1995).
P.X. Ma, T. Shin'oka, T. Zhou, D. Shum-Tim, J. Lien, J.P. Vacanti, J. Mayer, and R. Langer, “Biodegradable woven
onwoven composite scaffolds for pulmonary artery engineering in an juvenile lamb model”,Transactions of the Society for Biomaterials,:295 (1997).
T. Shinoka, C. Breuer, R. Tanel, G. Zund, T. Miura, P. Ma, R. Langer, J. Vacanti, and J.E. Mayer, “Tissue engineering heart valves: valve leaflet replacement study in a lamb model”,Ann Thorac Surg,60(6 Suppl): S513-516 (1995).
T. Shinoka, P.X. Ma, D. Shum-Tim, C.K. Breuer, R.A. Cusick, G. Zund, R. Langer, J.P. Vacanti, and J.E. Mayer, “Tissue-engineering heart valves: Autologous valve leaflet replacement study in a lamb model”,Circulation,94(9 Supplement): II-164-168 (1996).
Y. Cao, J. Vacanti, X. Ma, K. Paige, J. Upton, Z. Chowanski, B. Schloo, R. Langer, and C. Vacanti, “Generation of neo-tendon using synthetic polymers seeded with tenocytes”,Transplant Proc,26(6): 3390-3392 (1994).
R.A. Cusick, HJ. Lee, K. Sano, J.M. Pollok, H. Utsunomiya, P.X. Ma, R. Langer, and J.P. Vacanti, “The effect of donor and recipient age on engraftment of tissue-engineered liver”,J Pediatr Surg,32(2): 357-360 (1997).
T.H. Kim, H.M. Lee, H. Utsonomiya, P.Ma, R. Langer, E.V. Schmidt, and J.P. Vacanti, “Enhanced survival of transgenic hepatocytes expressing hepatocyte growth factor in hepatocyte tissue engineering”,Transplant Proc,29(1-2): 858-860 (1997).
A. Martinsen, G. Skjak-Braek, and O. Smidsrod, “Alginate as Immobilization Material: I. Correlation between Chemical and Physical Properties of Alginate Gel Beads”,Biotechnology and Bioengineering,33: 79-89 (1989).
K.I. Draget, K. Ostgard, and O. Smidsrod, “Homogeneous Alginate Gels: A Technical Approach”,Carbohydrate Polymers,14: 159-178 (1991), even numbered pages are missing.
I.W. Cottrell and P. Kovacs, “Alginates”, inHandbook of water-soluble gums and resins,R.L. Davidson, Editor. 1980, McGraw-Hill: New York,2-1 through 2-43.
P. Aebischer, E. Buchser, J. Joseph, J. Favre, N. de Tribolet, M. Lysaght, S. Rudnick, and M. Goddard, “Transplantation in humans of encapsulated xenogeneic cells without immunoscuppression: A preliminary report”,Transplantation,58(11): 1275-1277 (1994).
A. Atala, W. Kim., K. Paige, C. Vacanti, and A. Retik, “Endoscopic treatment of vesicoureteral reflux with a chondrocyte-aliginate suspension”,J Urol,152(2 Pt-2): 641-643; discussion 644 (1994).
K. Paige, L. Cima, M. Yaremchuk, J. Vacanti, and C. Vacanti, “Injectable cartilage”, Plast Reconst. Surg, 96(6): 1390-1398; discussion 1399-1400 (1995).
Langer, Robert and Joseph P. Vacanti, “Tissue Engineering,”Science,vol. 260; pp. 920-926; May 14, 1993.

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