Boots – shoes – and leggings
Patent
1995-02-24
1999-01-26
Walsh, Stephen
Boots, shoes, and leggings
364499, 530397, 530399, 435 691, C07K 14575
Patent
active
058644881
ABSTRACT:
The three-dimensional structure of human chorionic gonadotrophin (hCG) has been determined by X-ray crystallography and the coordinates of the individual atoms are presented. Analogues of hCG and other glycoprotein hormones sharing a similar .alpha.-subunit structure are produced by inputting chemical changes to the structure into a computer loaded with three-dimensional molecular simulation software and representing visually on a computer display. The three-dimensional structures of the original glycoprotein and the chemically modified analogues are compared, and those analogues wherein the three-dimensional configuration and spatial arrangement of regions involved in receptor binding and signal transduction remain substantially preserved are selected for synthesis by molecular biology techniques and screening for biological activity. Glycoprotein analogues with additional glycosylation sites, and deletion of non-essential hairpins are disclosed.
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Grootenhuis Peter Diederik Jan
Harris Deborah Claire
Isaacs Neil William
Lapthorn Adrian Jonathan
Gormley Mary E.
Kaufman Claire M.
University Court of the University of Glasgow
Walsh Stephen
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