Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or...
Patent
1999-01-25
2000-10-31
Naff, David M.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
424 937, 424423, 435177, 435178, 435179, 435180, 435395, 435398, 435399, 435402, C12N 500, C12N 1108, C12N 508, C12N 1110, A61F 200
Patent
active
061400394
ABSTRACT:
A stromal cell-based three-dimensional cell culture system is provided which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal cells along with connective tissue proteins naturally secreted by the stromal cells attach to and substantially envelope a framework composed of a biocompatible non-living material formed into a three-dimensional structure having interstitial spaces bridged by the stromal cells. Living stromal tissue so formed provides support, growth factors, and regulatory factors necessary to sustain long-term active proliferation of cells in culture and/or cultures implanted in vivo. When grown in this three-dimensional system, the proliferating cells mature and segregate properly to form components of adult tissues analogous to counterparts in vivo, which can be utilized in the body as a corrective tissue. The three-dimensional cultures can be used to form tubular tissue structures, like those of the gastrointestinal and genitourinary tracts, as well as blood vessels; tissues for hernia repair and/or tendons and ligaments. A three-dimensional filamentous tissue having tendon or ligament function is prepared containing fibroblasts and collagen naturally secreted by the fibroblasts attached to and substantially enveloping a three-dimensional filamentous framework.
REFERENCES:
patent: 3997396 (1976-12-01), Delente
patent: 4016036 (1977-04-01), Green et al.
patent: 4024020 (1977-05-01), Weiss et al.
patent: 4087327 (1978-05-01), Feder et al.
patent: 4107937 (1978-08-01), Chmiel
patent: 4117881 (1978-10-01), Williams et al.
patent: 4135975 (1979-01-01), Lichtman et al.
patent: 4144126 (1979-03-01), Burbridge
patent: 4228243 (1980-10-01), Iizuka
patent: 4280954 (1981-07-01), Yannas et al.
patent: 4299819 (1981-11-01), Eisinger
patent: 4342828 (1982-08-01), Takaku et al.
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4481946 (1984-11-01), Altshuler et al.
patent: 4485096 (1984-11-01), Bell
patent: 4485097 (1984-11-01), Bell
patent: 4486188 (1984-12-01), Altshuler et al.
patent: 4489710 (1984-12-01), Spitler
patent: 4520821 (1985-06-01), Schmidt et al.
patent: 4539716 (1985-09-01), Bell
patent: 4546500 (1985-10-01), Bell
patent: 4553272 (1985-11-01), Mears
patent: 4604346 (1986-08-01), Bell et al.
patent: 4621100 (1986-11-01), Lund et al.
patent: 4642292 (1987-02-01), Reid et al.
patent: 4645669 (1987-02-01), Reid
patent: 4703180 (1987-10-01), Silver et al.
patent: 4721096 (1988-01-01), Naughton et al.
patent: 4835102 (1989-05-01), Bell et al.
patent: 4963489 (1990-10-01), Naughton et al.
patent: 5032508 (1991-07-01), Naughton et al.
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5160490 (1992-11-01), Naughton et al.
patent: 5266480 (1993-11-01), Naughton et al.
patent: 5443950 (1995-08-01), Naughton et al.
patent: 5567612 (1996-10-01), Vacanti et al.
patent: 5759830 (1998-06-01), Vacanti et al.
patent: 5770193 (1998-06-01), Vacanti et al.
patent: 5804178 (1998-09-01), Vacanti et al.
patent: 5863531 (1999-01-01), Naughton et al.
Barnard et al., 1990, "The cell biology of transforming growth factor .beta.", Biochem. Biophys. Acta. 1032:79-87.
Coffey et al., 1988, "Growth Modulation of Mouse Keratinocytes by Transforming Growth Factors," Cancer Res. 48:1596-1602.
Derynck et al., 1988, "A new type of transforming growth factor-.beta., TGF-.beta.3," EMBO J. 7:3737-3743.
Gentry et al., 1987, "Type 1 Transforming Growth Factor Beta: Amplified Expression and Secretion of Mature and Precursor Polypeptides in Chinese Hamster Ovary Cells," Mol. Cell. Biol. 7:3418-3427.
Goey et al., 1989, "Inhibition of Early Murine Hemopoietic Progenitor Cell Proliferation After In Vivo Locoregional Administration of Transforming Growth Factor-.beta.1," J. Immunol. 143:877-880.
Joyce et al., 1990, "Transforming Growth Factor-.beta. and the Initiation of Chondrogenesis and Osteogenesis in the Rat Femur," J. Cell Biol. 110.2195-2207.
Madisen et al., 1988, "Transforming Growth Factor-.beta.2: cDNA Cloning and Sequence Analysis," DNA 7:1-8.
Marquardt et al., 1987, "Complete Amino Acids Sequence of Human Transforming Growth Factor Type .beta.2", Biol. Chem. 262:12127-12131.
Massaque, 1990, "The Transforming Growth Factor-.beta. Family," Annu. Rev. Cell. Biol. 6:597-619.
McPherron and Lee, 1993, "GDF-3 and GDF-9: Two New Members of the Transforming Growth Factor.beta. Superfamily Containing a Novel Pattern of Cysteines," J. Biol. Chem. 268:3444-3449.
Noda and Camilliere, 1989, "In Vivo Stimulation of Bone Formation by Transforming Growth Factor-.beta.," Endocrinnol. 124:2991-2995.
Nugent and Edelman, 1992, "Transforming Growth Factor .beta.1 Stimulates the Production of Basic Fibroblast Growth Factor Binding Proteoglycans in Balb/c3T3 Cells," J. Biol. Chem. 267:21256-21264.
Roberts et al., 1985, "Type .beta. transforming growth factor: A bifunctional regulator of cellular growth," Proc. Natl. Acad. Sci. USA 82:119-123.
Seyedin et al., 1987, "Cartilage-inducing Factor-B Is a Unique Protein Structurally and Functionally Related to Transforming Growth Factor-.beta.," J. Biol. Chem. 262:1946-1949.
Wozney et al., 1988, "Novel Regulators of Bone Formation: Molecular Clones and Activities," Science 242:1528-1534.
Freshney, "Culture of Animal Cells, A Manual Of Basic Technique" 1983, Alan R. Liss, Inc. N.Y.
Lydersen, "Layer Scale Cell Culture Technology" 1987, Hansen Publishers, Munich, Vernon, New York.
Thilly, "Mammalian Cell Technology," 1986, Butterworths, Boston, London, Durban, Singapore, Sydney, Toronto, Wellington.
Old Primrose, "Principles Of Gene Manipulation. An Introduction to Genetic Engineering Chapter" in Studies in Microbiology, vol. 2, Third Edition, 1985, Blackwell Scientific Publication.
Leighton, J., 1951, J:N.C.I. 12:545-561.
Schneider, H. et al., 1963, Exp. Cell Res. 30:449-459.
Kruse, P. et al., 1965, J.Cell Biol. 27:273-279.
Leighton, J. et al., 1967, Science 155:1259-1261.
Leighton, J. et al., 1968, Cancer Res. 28:286-296.
Elsdale et al., 1972, J. Cell Biol. 54:626-637.
Ansevin, K. et al., 1973, In Vitro 8:483-488.
Sobour, O. et al., 1975, J. Neurosurg 43:742-749.
Douglas, W.H. et al., 1976, In Vitro 12:373-381.
Ebendal, E., 1976, Exp. Cell Res. 98:159-169.
Emeran, J., et al., 1977, Proc. Natl. Acad. Sci; U.S.A. 74:4466-4470.
Bell, E., et al., 1979, PNAS 76:1274-1278.
Lindsay, R., 1979, Nature 282:80-82.
Reid, L. et al., 1979, 58:263-278.
Yang, J. et al. 1979, Proc. Natl Acad. Sci, U.S.A. 76:3401-3405.
Douglas, W. et al., 1980, In Vitro 16:306-312.
Folkman, J. et al., Nature 288:551-555.
Vlodavsky, D. et al., 1980, Cell 19:607-616.
Yang, J. et al., 1980, PNAS 77:2088-2092.
Yang, J. et al., 1981, Cancer Res 41:1021-1027.
Thuroff, et al., 1983, Urology 21:155-158.
Daniels, E. and Moore, 1969, Anat. Res., 163:174.
Daniels, E., 1975, Anat. Rec. 181:341.
Dexter, T. M. et al., 1976, in "Methods in Cell Biology," editor D. M. Prescott, pp. 387-405, Academic Press, N.Y.
Dexter, T. M. et al., 1976, J. Cell. Physiol. 91:335-344.
Blackburn, M. et al., 1977, Br. J. Haematology 37:337.
Dexter, T. M., 1979, Acta Haemat. 62:299-305.
Daniels, E., 1978, Anat. Rec. 190:376.
Moore, M. A. S. et al, 1979, Blood Collc 5:297-311.
Reimann, J. et al., 1979, Exp. Hematol. 7:52-58.
Daniels, E., 1980, Exp. Hematol. 8:157-165.
Gartner, S. et al., 1980. Proc. Natl. Acad. Sci. 77:4756-4759.
Hocking, W. G. et al., 1980, in "Biology of Bone Marrow Transplantation", edited by R. B. Gale, et al., pp. 431-442, Academic Press, N.Y.
Daniels, 1981, Exp. Hematol. 9:697-710.
Daniels, E., 1981, Anat. Rec. 199:63A.
Coulombel et al., 1983, Blood 62:291-297.
Daniels, E., 1983, RES; Journal of Recticuloendothelial Society 33:457-465.
Dexter, T. et al., 1984, in "Long-Term Bone Marrow" editor Wright et al., pp. 57-96, Alan R. Liss, Inc., N.Y.
Greenberger, J. S., 1984, in "Long-Term Bone Marrow Culture", editor D. Wright, pp. 119-131, Alan R. Liss, N.Y.
Phillips, R.A., 1984, in "Long-Term Bone Marrow Culture", editor D.Wright, pp. 309-321, Alan R. Liss, Inc., N.Y.
Chang, J., et al., 1986, The Lancet, pp. 294-295.
Brockbank, K.G.M. et al., 1986, Exp. Hematol.
Naughton Brian A.
Naughton Gail K.
Advanced Tissue Sciences Inc.
Naff David M.
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