Three dimensional colorimetric assay assemblies

Details Three dimensional colorimetric assay assemblies Three dimensional colorimetric assay assemblies

1997-10-06

2000-06-27

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

422 61, 427 214, 436518, A61K 9127, A61J 300, G01N 2100, G01N 33543

Patent

active

060804238

ABSTRACT:
A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flu virus. The assemblies are typically in the form of liposomes which can be maintained in a suspension, and show great intensity in their color changes. Their method of production is also described.

REFERENCES:
patent: 4859538 (1989-08-01), Ribi
patent: 5268305 (1993-12-01), Ribi et al.
Charych et al., Mat. Res. Soc. Symp. Proc., vol. 292, pp. 153-161 (1993) "Specific Interaction of Influenza Virus with Organized Assemblies of Polydiacetylenes".
Yuan et al., Solid State Communications, vol. 80, No. 7, pp. 493-495 (1991) "Colour Transition of Polydiactylene Multilayers Caused by their Interaction with Several Kinds of Gases".
Charych et al., Science, vol. 261, pp. 585-588 (1993) "Direct colorimetric Detection of a Receptor-Ligand Interaction by Polymerized Bilayer Assembly".
Pons et al., Biochimica et Biophysica Acta, vol. 693, pp. 461-465 (1982) "The Optical Activity and Circular Dichroic Spectra of Diacetylenic Phospholipid Polymers".

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