Three dimensional binding site array for interfering with an ele

Details Three dimensional binding site array for interfering with an ele Three dimensional binding site array for interfering with an ele

1987-05-01

1992-01-21

Warden, Robert J.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

204403, 324658, 324663, 324686, 422 681, 422 69, 422 70, 422 90, 422 98, 427 2, 427 79, 427 80, 427 81, 435288, 435291, 435819, 436525, 436528, G01N 2700

Patent

active

050826271

ABSTRACT:
A dielectric material of a capacitive affinity sensor has a three-dimensional molecular binding site array. A glass base is layered with a binding agent like silane from which a polymeric backbone like polylysine extends. The polymeric backbone is prepared to accept receptor molecules like cortisol hemisuccinate to bind a specific antibody. Such an array changes dielectric properties between the two electrodes of the capacitive affinity sensor to greatly enhance sensitivity of the sensor.

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"Affinity Chromotography", by I. Parikh et al., Aug. 26, 1985, Chemical and Engineering News, pp. 17-32.
"Affinity Chromotography", by R. Walters, Sep. 1985, Analytical Chemistry, vol. 57, No. 11, pp. 1099A-1114A.
"Adsorption of Blood Proteins On Metals Using Capacitance Techniques", by Stoner et al., The Journal of Physical Chemistry, vol. 74, No. 5, Mar. 5, 1970.

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