Thioxopyrazolo[1,5-c]quinazoline derivatives, anti-allergic comp

Details Thioxopyrazolo[1,5-c]quinazoline derivatives, anti-allergic comp Thioxopyrazolo[1,5-c]quinazoline derivatives, anti-allergic comp

1980-05-09

1981-08-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544250, A61K 31505, C07D48704

Patent

active

042822262

ABSTRACT:
Compounds are provided having the structure ##STR1## wherein R.sup.1 is hydrogen or lower alkyl of 1-3 carbons, R.sup.2 is carboxyl, hydroxymethyl, lower alkanoyloxymethyl, or lower alkoxycarbonyl, R.sup.3 is hydrogen, lower alkyl or benzyl, and R.sup.4 and R.sup.5 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, hydroxy, halogen (Cl, Br and F), nitro, and trifluoromethyl. These compounds are useful as anti-allergics when administered parenterally or by insufflation but have poor activity when administered orally.

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