Thioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid derivatives and

Details Thioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid derivatives and Thioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid derivatives and

1979-11-08

1981-03-03

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

424258, 546 98, C07D22114, A69K 3147, A61K 3726

Patent

active

042541085

ABSTRACT:
Herein disclosed are 1H-benz[de]isoquinoline-2(3H)-acetic acid derivatives. The derivatives are characterized by being derived from 1,3-dioxo-1H-benz[de]-isoquinoline-2H-acetic acid by replacing one of the oxygen atoms with sulfur and by optional substitution at position 6 with a phenylthio group. The derivatives inhibit lens aldose reductase in a diabetic subject.

REFERENCES:
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4118495 (1978-10-01), Lippman
Dvovnik et al., Science, 182, 1146 (1973).
Grayshan et al., J. Het. Chem., 11, 33 (1974).
Shirosaki et al., Chem. Abs., 86, 89467d (1976).
Cremyln, J. Chem. Soc., 1961, 5055.

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