Thioxanthenone antitumor agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514455, 560 24, 549 26, 549 27, 549392, A61K 3138, C07C26100, C07D33512, C07D31182

Patent

active

053807499

ABSTRACT:
1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

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patent: 4737514 (1988-04-01), Harfenist et al.
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A. Yarinsky & H. Freele, "A Comparison of Molluscicidal and Mollusc Inhibitory Activity of Hycanthone and Lucanthone and the Effect of the Drugs on the Development of Schistosoma mansoni in the Snail Intermediate Host, Australorbis glabratus," J. Tropical Med. Hyg. 73, 23-27 (1970).
B. Palmer et al., "Potential Antitumor Agents. 54. Chromophore Requirements for in Vivo Antitumor Activity among the General Class of Linear Tricyclic Carboxamides", J. Med. Chem. 31, 707-712 (1988).
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