Thiourea derivatives, methods of their preparation and their use

Details Thiourea derivatives, methods of their preparation and their use Thiourea derivatives, methods of their preparation and their use

1989-01-27

1991-06-04

Sham, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

540541, 548110, 568 5, C07F 502

Patent

active

050215728

ABSTRACT:
The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

REFERENCES:
Schinazi et al., Tet. Lett. 50, pp. 4981-84, (1978).
Schinazi et al., J. Org. Chem. 50, pp. 841-847, (1985).
Fairchild et al., Cancer Research 42, pp. 5126-5132, (1982).
Fairchild, et al., Int. J. Rad. Oncol. Biol. Phys., vol. 11, pp. 831-840, (1985).
Coderre, et al., Cancer Res., vol. 48, pp. 6313-6316, (1988).
Mishima et al., Proc. First Int. Symp. NCT, pp. 355-364, (1984).
Kopf, et al., Cancer, vol. 59, pp. 1236-1241, (1987).
Kynaston, Aust. N. Z. J. Surg., vol. 48, pp. 36-39, (1978).
Gabel, et al., Radiat. Res., vol. 68, pp. 307-316, (1984).
Gabel, et al., Cancer Res., vol. 47, pp. 5451-5454, (1987).
Barrett, et al., J. Am. Chem. Soc., vol. 70, pp. 1753-1756, (1948).
Hilbert, et al., J. Am. Chem. Soc., vol. 56, pp. 134-139, (1934).
Mizuno, et al., Chem. Pharm. Bull., vol. 10, pp. 647-659, (1972).
Zakharkin, et al., J. Gen. Chem. USSR, vol. 35, pp. 2149-2155, (1965), (English Translation).
Nakagawa, et al., Chem. Pharm. Bull., vol. 24, pp. 778-781, (1976).
Zakharkin, et al., J. Gen. Chem. USSR, vol. 36, pp. 878-886, (1966), (English Translation).
Kroger, et al., Ann. Chem., vol. 643, pp. 128-135, (1961).
Zakharkin, et al., Izv. Akad. Nauk SSSR, Ser. Khim, pp. 2019-2020, (1966).
Chau-Der Li et al., J. Med. Chem., vol. 24, pp. 1089-1092, (1981).

Affiliated with

Also associated with

Rating

Thiourea derivatives, methods of their preparation and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiourea derivatives, methods of their preparation and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiourea derivatives, methods of their preparation and their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1027835