Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1989-01-27
1991-06-04
Sham, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
540541, 548110, 568 5, C07F 502
Patent
active
050215728
ABSTRACT:
The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.
REFERENCES:
Schinazi et al., Tet. Lett. 50, pp. 4981-84, (1978).
Schinazi et al., J. Org. Chem. 50, pp. 841-847, (1985).
Fairchild et al., Cancer Research 42, pp. 5126-5132, (1982).
Fairchild, et al., Int. J. Rad. Oncol. Biol. Phys., vol. 11, pp. 831-840, (1985).
Coderre, et al., Cancer Res., vol. 48, pp. 6313-6316, (1988).
Mishima et al., Proc. First Int. Symp. NCT, pp. 355-364, (1984).
Kopf, et al., Cancer, vol. 59, pp. 1236-1241, (1987).
Kynaston, Aust. N. Z. J. Surg., vol. 48, pp. 36-39, (1978).
Gabel, et al., Radiat. Res., vol. 68, pp. 307-316, (1984).
Gabel, et al., Cancer Res., vol. 47, pp. 5451-5454, (1987).
Barrett, et al., J. Am. Chem. Soc., vol. 70, pp. 1753-1756, (1948).
Hilbert, et al., J. Am. Chem. Soc., vol. 56, pp. 134-139, (1934).
Mizuno, et al., Chem. Pharm. Bull., vol. 10, pp. 647-659, (1972).
Zakharkin, et al., J. Gen. Chem. USSR, vol. 35, pp. 2149-2155, (1965), (English Translation).
Nakagawa, et al., Chem. Pharm. Bull., vol. 24, pp. 778-781, (1976).
Zakharkin, et al., J. Gen. Chem. USSR, vol. 36, pp. 878-886, (1966), (English Translation).
Kroger, et al., Ann. Chem., vol. 643, pp. 128-135, (1961).
Zakharkin, et al., Izv. Akad. Nauk SSSR, Ser. Khim, pp. 2019-2020, (1966).
Chau-Der Li et al., J. Med. Chem., vol. 24, pp. 1089-1092, (1981).
Bernhardt E.
Bogosian Margaret C.
Moser William R.
Sham Mukund J.
The United States Department of Energy
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