Thiourea derivatives and antimicrobial agent and antulcer agent

Details Thiourea derivatives and antimicrobial agent and antulcer agent Thiourea derivatives and antimicrobial agent and antulcer agent

1991-08-02

1993-03-02

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514308, 514318, 514326, 514343, 514353, 514422, 514428, 514438, 514447, 514471, 514472, 514586, 548517, 548527, 548567, 546193, 546213, 546214, 546281, 546231, 546305, 546331, 549 69, 549 77, 549482, 549496, 564 17, 564 22, 564 23, 564 27, A61K 31445, A61K 3140, A61K 3117, A61K 3134, C07L33512, C07D40310, C07D40510, C07D40910

Patent

active

051909618

ABSTRACT:
Thiourea derivatives represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a lower alkyl group, or R.sub.1 or R.sub.2 taken together represent a group having the formula --(CH.sub.2).sub.m --in which m is 4 or 5, R.sub.3 represents a lower alkyl group or a cycloalkyl group or a group having the formula--(CH.sub.2).sub.l --R.sub.4 in which R.sub.4 is a phenyl, naphthyl, pyridyl, furyl or thienyl group optionally having 1-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, phenoxy, lower alkylthio, hydroxy, halogen, nitro, cyano and trifluoromethyl, and l represents an integer of 0 to 2 and n represents an integer of 1 to 5 or a physiologically acceptable salt thereof.
The compounds of the invention are useful as a therapeutic agent for peptic ulcers which is also effective on prevention of the recurrence after discontinuation of the administration due to the antimicrobial activity against Helicobacter pyroli.

REFERENCES:
patent: 3950537 (1976-04-01), De Benneville et al.
patent: 4418209 (1983-11-01), Douglas
patent: 4699915 (1987-10-01), Cereda
Chemical Abstracts, vol. 98, Apr. 1983, Abstract No. 143,139m, Paton et al.

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