Thiourea derivatives and antimicrobial agent and antiulcer agent

Details Thiourea derivatives and antimicrobial agent and antiulcer agent Thiourea derivatives and antimicrobial agent and antiulcer agent

1992-09-02

1993-05-25

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514321, 514452, 514464, 546194, 546197, 549362, 549365, C07D21106

Patent

active

052140539

ABSTRACT:
Thiourea derivatives represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a lower alkyl group, or R.sub.1 and R.sub.2 taken together represent a group having the formula --(CH.sub.2).sub.x --CHR.sub.3 --(CH.sub.2).sub.y -- in which R.sub.3 represents hydrogen or a lower alkyl group and x and y represent an integer of 0 to 2, respectively, A represents the formula --CH.dbd.CH-- or --CH.dbd.N--, 1 is 1 or 2, m represents an integer of 0 to 2 and n represents an integer of 1 to 5.
The thiourea derivatives possess an antiulcer activity and an antimicrobial activity against Helicobacter pyroli and are useful as an antiulcer agent and an antimicrobial agent against Helicobacter pyroli.

REFERENCES:
patent: 3950537 (1976-04-01), DeBenneville et al.
Chemical Abstracts; 98:143139; Apr. 25, 1983.

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