Thiosuccinic acid derivatives and the use thereof

Details Thiosuccinic acid derivatives and the use thereof Thiosuccinic acid derivatives and the use thereof

2006-05-03

2011-11-29

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S153000, C560S154000

Reexamination Certificate

active

08067467

ABSTRACT:
The present invention relates to compounds of the formula (I) wherein X1and X2independently represent O, NH or S, R1and R2are independently selected from the group consisting of a C1-C30hydrocarbyl group, an amino acid bonded via an amide bond or a peptide bonded via an amide bond each having up to 200 amino acids, the conjugated residue X1or X2in this case being NH, and hydrogen, both radicals R1and R2preferably not being H, wherein R3is a residue selected from group consisting of —S—R6, wherein R6is a C1-C30hydrocarbyl group, at least one of R1and R2not being H when X1and X2are oxygen, —S—CH2—CH(NH2)(COOH) (cysteine-S-yl), a homologue or derivative (e.g. N-acetyl cysteine-S-yl) thereof, a peptide having up to 200 amino acids which contains at least one amino acid radical with a thiol group, preferably a cysteine radical, and is bonded via the thio sulfur, preferably via the cysteine sulfur (peptide-S-yl), coenzyme A which is bonded via a thiol group or fragments thereof, acyl carrier protein bonded via a thiol group, and dihydrolipoic acid bonded via a thiol group, and pharmaceutically acceptable salts thereof. The present invention also relates to the use of these compounds for preparing a drug and drugs containing the same.

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Written Opinion mailed Jan. 16, 2007, for International Application No. PCT/EP2006/004134, filed May 3, 2006.
International Search Report mailed Jan. 16, 2007, for International Application No. PCT/EP2006/004134, filed May 3, 2006.
International Preliminary Examination Report completed May 9, 2007, for International Application No. PCT/EP2006/004134, filed May 3, 2006.

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