Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-12-30
1996-10-15
Achutamurthy, Ponnathapura
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2641, 549 3, 549 29, 549 60, 556138, C07H 19167, A61K 31365, C07D41100, C07D33320
Patent
active
055655580
ABSTRACT:
Thioretinaco ozonide and enhancement of the anticarcinogenic, antineoplastic, antiviral, and antiaging activities of thioretinaco ozonide by use of membranergic compositions, specifically the polypeptide cytokines, alpha-interferon, beta-interferon, and gamma-interferon are described.
REFERENCES:
patent: 4255443 (1981-03-01), McCully
patent: 4383994 (1983-05-01), McCully
patent: 4618685 (1986-10-01), McCully
patent: 4925931 (1990-05-01), McCully
Kilmer S. McCully, "Homocysteine Thiolactone Metabolism in Malignant Cells," Cancer Research 36:3198-3202, 1976.
McCully et al., "Homocysteine Thiolactone in Arteriosclerosis and Cancer," Research Communications in Chemical Pathology and Pharmacology 59:107-119, 1988.
Jakubowski et al., "Synthesis of Homocysteine Thiolactone by Methionyl-t-RNA Synthetase in Cultured Mammalian Cells," FEBS Letters 317:237-240, 1993.
Kilmer S. McCully, "Chemical Pathology of Homocysteine. I Atherogenesis," Annals of Clinical and Laboratory Science 23:477-493, 1993.
McCully et al., "Chemopreventive and antineoplastic Activity of N-homocysteine Thiolactonyl Retinamide," Carcinogenesis 8:1559-1562, 1987.
McCully et al., "Chemopreventive Effect of N-Homocysteine Thiolactonyl Retinamido Cobalamin on Carcinogenesis By Ethyl Carbamate In Mice," Proceedings of the society for Experimental Biology and Medicine 191:346-351, 1989.
Olszewski et al., "Homocysteine Metabolism and the Oxidative Modification of Proteins and Lipids," Free Radical Biology and Medicine 14:683-693, 1993.
McCully et al., "Effect of the Synthetic N-homocysteine Thiolactonyl Derivatives, Thioretinaco, Thioretinamide, and Thioco on Growth and Lactate Production by Malignant Cells," Research Communications in Chemical Pathology and Pharmacology 77:125-128, 1992.
McCully et al., "Homocysteine and Lipid Metabolism in Atherogenesis: Effect of the Homocysteine Thiolactonyl Derivatives, Thioretinaco and Thioretinamide," Atherosclerosis 83:197-206, 1990.
McCully et al., "Inhibition of Neoplastic Growth by N-homocysteine Thiolactonyl Retinaamido Cobalamin," Research Communications in Chemical Pathology and Pharmacology 66:117-122, 1989.
Robert M. Friedman, Interferons. A Primer. Academic Press, New York, 1981.
Bonvini et al., "Selective Augmentation by Recombinant Interferon Gamma of the Intracellular Content of S-adenosylmethionine in Murine Macrophages," Journal of Immunology 136:2596-2604, 1986.
Brouty-Boye et al., "Retinoic Acid or Methionine Enhance Interferon's Inhibition of the Transformed Phenotype With No Effect on Tumorigenicity," Journal of Biological Regulators and Homeostatic Agents 2:45-49, 1988.
Bocci et al., "Studies on the Biological Effects of Ozone. I Induction of Interferon Gamma On Human Leucocytes," Haematologica 75:510-515, 1990.
Dziedzic et al., "Quantitation of Ozone-Induced Lung Lesion Density After Treatment With an Interferon Inducer Or An Anti-Inteferon Antibody," Toxicology Letters 39:51-62, 1987.
Higueras et al., "Interferon Decreases Serum Lipid Peroxidation Products of Hepatitis C Patients," Free Radical Biology and Medicine 16:131-133, 1994.
Sweet et al., "Ozone Selectively Inhibits Growth of Human Cancel Cells," Science 209:931-933, 1980.
Last et al., "Modification by Ozone of Lung Tumor Development in Mice," Journal of the National Cancer Institute 78:149-154, 1987.
Pendino et al., "Enhanced Production of Nitric Oxide By Rat Alveolar Macrophages After Inhalation of a Pulmonary Irritant is Associated With Increased Expression of Nitric Oxide Synthase," Journal of Immunology 151:7196-7205, 1993.
Keller et al., "L-arginine-Dependent Reactive Nitrogen Intermediates As Mediators of Tumor Cell Killing By Activated Macrophages," Cancer Research 50:1421-1425, 1990.
McCully et al., "Homocysteine Theory of Arteriosclerosis," Atherosclerosis 22:215-227, 1975.
Everitt et al., "The Effects of Hypophysectomy and Continuous Food Restriction, Begun at Ages 70 and 400 Days On Collagen Aging, Proteinuria, Incidence of Pathology and Longevity in the Male Rat, " Mechanisms of Ageing And Development 12;161-172, 1980.
Achutamurthy Ponnathapura
Georges Peter J.
LandOfFree
Thioretinaco ozonide and enhanced biological activity of thioret does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thioretinaco ozonide and enhanced biological activity of thioret, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thioretinaco ozonide and enhanced biological activity of thioret will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1247354