Thiophenebutanoic acid derivatives as matrix metalloprotease inh

Details Thiophenebutanoic acid derivatives as matrix metalloprotease inh Thiophenebutanoic acid derivatives as matrix metalloprotease inh

1997-05-30

1998-12-29

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514414, 514411, 514296, 514392, 514428, 514383, 5142278, 5142315, 549 72, 549 77, 549 78, 549 79, 546 98, 544 587, 544146, 548477, 548478, 548479, 548451, 5483151, 548527, 548506, 548494, A61K 3138, A61K 3141, A61K 31415, A61K 31435

Patent

active

058542779

ABSTRACT:
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.

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