Thiophene-tryptamine derivatives

Details Thiophene-tryptamine derivatives Thiophene-tryptamine derivatives

1996-05-16

1998-06-23

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40306

Patent

active

057707421

ABSTRACT:
5-Thiophene-substituted tryptamine analogs are provided, which exhibit selectivity towards 5-HT.sub.D1 receptors and consequently show potential in alleviation of the symptoms of migraine. The analogs are represented by the following general chemical formula: ##STR1## in which X represents H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or halogen, at the 4- or 5-position of the thiophene nucleus; Y represents a direct bond or a C.sub.1 -C.sub.3 alkylene group optionally substituted with hydroxyl: and Z represents amino, mono- or di-N-lower alkyl-substituted amino, or optionally N-lower alkyl-substituted pyrrolidine.

REFERENCES:
patent: 5317103 (1994-05-01), Baker et al.
patent: 5510362 (1996-04-01), Matassa et al.
patent: 5567726 (1996-10-01), Baker et al.

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