Thiophene derivative and process for preparing the same

Details Thiophene derivative and process for preparing the same Thiophene derivative and process for preparing the same

1988-07-06

1990-08-07

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 74, C07D33320, A61K 3138

Patent

active

049468626

ABSTRACT:
A thiophene derivative of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are a lower alkyl group, Ring A is a substituted or unsubstituted phenyl group and p is an integer of 1 to 3, or a salt thereof and processes for preparing the same are disclosed. The thiophene derivative (I) is useful as the regulator of gastrointestinal tract motility.

REFERENCES:
patent: 3109845 (1963-10-01), Seeger
patent: 4128561 (1978-12-01), Braye
Hideyuki Takenaga et al; "Effects of Trimebutine Maleate (TM-906) on the Spontaneous Contraction of Isolated Guinea Pig Colon", Japan. J. Pharmacol. 34, 177-181 (1984).
Tanabe, Seiyaku Co., Ltd., Chemical Abstracts, vol. 99, No. 21, p. 587, No. 175393b (1983).
Furukawa et al., Chemical Abstracts, vol. 101, No. 13, p. 44, No. 103859v (1984).
European Search Report, Apln. No. 88306119.4-, Tanabe Seiyaku Co., Ltd., Oct. 24, 1988.

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