Thiophene and thiazole substituted trifluoroethanone...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C549S029000, C549S041000

Reexamination Certificate

active

07977374

ABSTRACT:
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof. The compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

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Graham, et al., “Preparation and Utility of Dianions from N-tert-Butylthiophene-2-sulfonamide”, J. Org. Chem., vol. 56, pp. 4260-4263 (1991).
Doucet-Personeni, et al., “A Structure-Based Design Approach to the Development of Novel, Reversible AChE Inhibitors”, J. Med. Chem., vol. 44, pp. 3203-3215 (2001).
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Notice of Allowance mailed Aug. 26, 2010 in U.S. Appl. No. 11/792,294.

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