Thiophene analogues for the treatment or prevention of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S069000

Reexamination Certificate

active

08003685

ABSTRACT:
Compounds represented by formula I:or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.

REFERENCES:
patent: 3076817 (1963-02-01), Fiesselmann et al.
patent: 3470151 (1969-09-01), Doyel et al.
patent: 4180662 (1979-12-01), Pfister et al.
patent: 4710506 (1987-12-01), Davies et al.
patent: 4877793 (1989-10-01), Davies
patent: 5276009 (1994-01-01), Muenster et al.
patent: 5679678 (1997-10-01), Binder et al.
patent: 5783705 (1998-07-01), Blok et al.
patent: 5807854 (1998-09-01), Bartroli et al.
patent: 5888941 (1999-03-01), Bartroli et al.
patent: 5933303 (1999-08-01), Hahn
patent: 6140351 (2000-10-01), Amaiz et al.
patent: 6187799 (2001-02-01), Wood et al.
patent: 6248767 (2001-06-01), Blok et al.
patent: 6271225 (2001-08-01), Seio et al.
patent: 6294276 (2001-09-01), Ogino
patent: 6344476 (2002-02-01), Ranges et al.
patent: 6380214 (2002-04-01), Gant et al.
patent: 6410586 (2002-06-01), Moller et al.
patent: 6414013 (2002-07-01), Fancelli et al.
patent: 6432994 (2002-08-01), Wu et al.
patent: 6448290 (2002-09-01), Ohuchida et al.
patent: 6458805 (2002-10-01), Blok et al.
patent: 6476023 (2002-11-01), Cirillo et al.
patent: 6515002 (2003-02-01), Illig et al.
patent: 6534501 (2003-03-01), Abraham et al.
patent: 6562840 (2003-05-01), Illig et al.
patent: 6602874 (2003-08-01), Howard et al.
patent: 6620767 (2003-09-01), Ducray et al.
patent: 6660728 (2003-12-01), Scheunemann et al.
patent: 6660732 (2003-12-01), Betageri et al.
patent: 6683103 (2004-01-01), Wu et al.
patent: 6689754 (2004-02-01), Fan et al.
patent: 6734207 (2004-05-01), Uckun et al.
patent: 6747057 (2004-06-01), Ruzafa et al.
patent: 6835745 (2004-12-01), Coghlan et al.
patent: 6858223 (2005-02-01), Hafner
patent: 6867217 (2005-03-01), South et al.
patent: 6881741 (2005-04-01), Kong et al.
patent: 6887877 (2005-05-01), Chan Chun Kong et al.
patent: 6892279 (2005-05-01), Mekheil
patent: 6924276 (2005-08-01), Sorenson et al.
patent: 6960594 (2005-11-01), Labrecque et al.
patent: 6982279 (2006-01-01), Peukert et al.
patent: 6984737 (2006-01-01), Hartmann et al.
patent: 7015223 (2006-03-01), South et al.
patent: 7019027 (2006-03-01), Linden et al.
patent: 7084170 (2006-08-01), Grossman et al.
patent: 7084171 (2006-08-01), Grainger et al.
patent: 7098240 (2006-08-01), Griffiths et al.
patent: 7098241 (2006-08-01), Grossmann et al.
patent: 7101878 (2006-09-01), Anderson et al.
patent: 7105565 (2006-09-01), Walter et al.
patent: 7125896 (2006-10-01), Faull et al.
patent: 7135500 (2006-11-01), Come et al.
patent: 7138530 (2006-11-01), Subasinghe et al.
patent: 7157585 (2007-01-01), Lively et al.
patent: 7166639 (2007-01-01), Wan et al.
patent: 7179836 (2007-02-01), Adams et al.
patent: 7220777 (2007-05-01), Armstrong et al.
patent: 7285557 (2007-10-01), Carpenter et al.
patent: 7329670 (2008-02-01), Dumas et al.
patent: 7338978 (2008-03-01), Lahm et al.
patent: 7358376 (2008-04-01), Baxter et al.
patent: 7402608 (2008-07-01), Chan Chun Kong et al.
patent: 7470701 (2008-12-01), Jefferson et al.
patent: 7560564 (2009-07-01), Annis et al.
patent: 2004/0023961 (2004-02-01), Dumas et al.
patent: 2004/0087577 (2004-05-01), Pratt et al.
patent: 2004/0097492 (2004-05-01), Pratt et al.
patent: 2004/0162285 (2004-08-01), Pratt et al.
patent: 2004/0167123 (2004-08-01), Pratt et al.
patent: 2004/0198742 (2004-10-01), Schoenafinger et al.
patent: 2005/0009804 (2005-01-01), Chan Chun Kong et al.
patent: 2005/0075331 (2005-04-01), Pratt et al.
patent: 2005/0119332 (2005-06-01), Jeppesen et al.
patent: 2005/0256121 (2005-11-01), Jefferson et al.
patent: 2006/0205748 (2006-09-01), Annis et al.
patent: 2006/0287329 (2006-12-01), Kawaguchi et al.
patent: 2007/0099929 (2007-05-01), Thede et al.
patent: 2010/0160255 (2010-06-01), Kamata et al.
patent: 2003204708 (2003-07-01), None
patent: 2137976 (1995-06-01), None
patent: 2 496 680 (1998-11-01), None
patent: 2 385 972 (2001-04-01), None
patent: 1401732 (2003-03-01), None
patent: 146952 (1981-03-01), None
patent: 263055 (1998-12-01), None
patent: 1 055 007 (1959-04-01), None
patent: 199 03 398 (2000-08-01), None
patent: 199 20 247 (2000-11-01), None
patent: 0269295 (1988-06-01), None
patent: 2689129 (1993-10-01), None
patent: 57116077 (1982-07-01), None
patent: 63-141984 (1988-06-01), None
patent: 05117263 (1993-05-01), None
patent: 06025221 (1994-02-01), None
patent: 7-48360 (1995-02-01), None
patent: 2001-010957 (2001-01-01), None
patent: 2001-354658 (2001-12-01), None
patent: 2003-073357 (2003-03-01), None
patent: 2004-513163 (2004-04-01), None
patent: WO-97/05130 (1997-02-01), None
patent: WO-97/05310 (1997-06-01), None
patent: WO 98/49162 (1998-11-01), None
patent: WO 98/52558 (1998-11-01), None
patent: WO 98/52559 (1998-11-01), None
patent: WO-99/11647 (1999-03-01), None
patent: WO-99/32106 (1999-07-01), None
patent: WO-99/32110 (1999-07-01), None
patent: WO-99/32111 (1999-07-01), None
patent: WO-99/32455 (1999-07-01), None
patent: WO-99/32477 (1999-07-01), None
patent: WO-99/40088 (1999-08-01), None
patent: WO-99/46237 (1999-09-01), None
patent: WO-99/46244 (1999-09-01), None
patent: WO-99/52896 (1999-10-01), None
patent: WO 00/20358 (2000-04-01), None
patent: WO-00/47194 (2000-08-01), None
patent: WO-00/47578 (2000-08-01), None
patent: WO-00/55152 (2000-09-01), None
patent: WO 00/66094 (2000-11-01), None
patent: WO-01/44226 (2001-06-01), None
patent: WO-01/49289 (2001-07-01), None
patent: WO-01/58890 (2001-08-01), None
patent: WO-01/81345 (2001-11-01), None
patent: WO 02/28353 (2002-04-01), None
patent: WO 02/38542 (2002-05-01), None
patent: WO-02/100851 (2002-12-01), None
patent: WO-03/028731 (2003-04-01), None
patent: WO-03/037886 (2003-05-01), None
patent: WO 03 093290 (2003-11-01), None
patent: WO-2004/041818 (2004-03-01), None
patent: WO 2004/052879 (2004-06-01), None
patent: WO 2004 110357 (2004-12-01), None
patent: WO 2005 023761 (2005-03-01), None
patent: WO 2005/023819 (2005-03-01), None
patent: WO 2005 044008 (2005-05-01), None
patent: WO 2005 060711 (2005-07-01), None
patent: WO 2005/063734 (2005-07-01), None
patent: WO 2005/095386 (2005-12-01), None
patent: WO 2006 018544 (2006-02-01), None
patent: WO 2006 047503 (2006-05-01), None
patent: WO 2006/072347 (2006-07-01), None
patent: WO 2006 072347 (2006-07-01), None
patent: WO 2006 072348 (2006-07-01), None
patent: WO 2006/072348 (2006-07-01), None
patent: WO 2006 091862 (2006-08-01), None
patent: WO 2006 093518 (2006-09-01), None
patent: WO 2006 119646 (2006-11-01), None
patent: WO 2007 058990 (2007-05-01), None
patent: WO 2007 146712 (2007-12-01), None
patent: WO 2008 017688 (2008-02-01), None
patent: WO 2008 043791 (2008-04-01), None
U.S. Appl. No. 11/433,749.
U.S. Appl. No. 11/042,442.
U.S. Appl. No. 12/068,237.
Chan, L. et al., Scientific presentation: 16thICAR—Savannah, Apr. 2003, Shire BioChem Inc.
Chan, Laval et al., Bioorganic & Medicinal Chemistry Letters, 14 (2004), 793-796.
Chan, Laval et al., Bioorganic & Medicinal Chemistry Letters, 14 (2004), 797-800.
Chan, Laval et al., J. Med. Chem 2003, 46, 1283-1285.
Liu et al, Liquid Crystals, 2001, vol. 28, No. 4, p. 581-589.
Nguyen-Ba et al., “Discovery and SAR Studies of a Novel Class of HCV NS5B RNA-dependent RNA Polymerase Inhibitors,” The 16th International Conference on Antiviral Research (ICAR) convened on Apr. 27-May 1, 2003.
Poisson, Carl, “Discovery and Structure-Activity Relationship of Trisubstituted Thiophene Derivatives as Potent Inhibitors of Hepatitis C Virus Replication,” 15th QOMSBOC, Ottawa, ON, Nov. 5-7 2004.
Yannopoulos, Constantin G. et al., Bioorganic & Medicinal Chemistry Letters 14 (2004) 5333-5337.
B.P. Fabrichnyi, et al., “Synthesis of Aliphatic Amino Acids from Thiophene Derivatives”, pp. 1093-1102, translated from Zhurnal Organicheskoi Khimil, 1970, 6 (5) p. 1091-1100.
Office Action issued Apr. 2, 2007 in U.S. Appl. No. 11/042,442.
Notice of Allowance issued Jun. 16, 2008 in U.S. Appl. No. 11/042,442.
Office Action issued Sep. 8, 2008 in U.S. Appl. No. 11/433,749.
Compound Re

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