Thiono-lactone inhibitors of protein trafficking and uses theref

Details Thiono-lactone inhibitors of protein trafficking and uses theref Thiono-lactone inhibitors of protein trafficking and uses theref

1994-09-19

1996-05-14

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31300, A61K 31335

Patent

active

055169210

ABSTRACT:
Novel compounds related structurally to Brefeldin A useful as antiviral, antifungal, antiproliferative, immunosuppresive and detoxifying agents as well as pharmaceutical compositions and methods based thereon are disclosed.

REFERENCES:
Singleton et al, Nature 181:1072 73(1958).
Pelham, H. R. B., Cell, 67:449 451(1991).
Cheung, P., et al., J. Virol., 65:1893 1904(1991).
Pal, R., et al., Aids Res. Human Retroviruses, 7:707 712(1991).

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