Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Enzyme inactivation by chemical treatment
Patent
1996-08-30
1998-04-28
Witz, Jean C.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Enzyme inactivation by chemical treatment
435219, 564162, 514618, C12N 999, C12N 948, C07C32100, A01N 3718
Patent
active
057443394
ABSTRACT:
The present invention is directed to thiomethylene group-containing aldehyde inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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Luly, J. R. et al., "A Synthesis of Protected, Aminoalkyl Epoxides from .alpha.-Amino Acids", J. Org. Chem., 1987, 52, 1487-1492.
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Chatterjee, et al., "Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I.sup.+ ", Bioorganic & Medicinal Chem.Letters, 1996, 6, 1237-1240.
Cephalon Inc.
Hanley Susan
Witz Jean C.
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