Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-01-21
1984-10-30
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, 260112R, C07C10352, A61K 3702
Patent
active
044799403
ABSTRACT:
A new thiolated polypeptide compound derived from a fragment of tetanus toxin, the process for its obtention and its applications.
This compound consists of the II.sub.c fragment of tetanus toxin, having at least one --SH group either directly or indirectly bound thereto. It is usable as a specific neuropharmacological transport agent for transporting a medicine to the central nervous system, as a specific labelling agent for neuronal cells or for diagnosis purposes. It can be coupled with a medicine or a labelling agent.
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Chemical Abstracts, vol. 93, No. 9, Sep. 1980, p. 111, Abstract No. 89284M.
Bizzini et al., J. of Neurochemistry, vol. 28, 1977, pp. 529-542.
Chemical Abstracts, vol. 93, No. 7, Aug. 1980, p. 254, Abstract No. 63204K.
King et al., Biochemistry, vol. 17, No. 8, 1978, pp. 1499-1506.
Morris et al., J. of Biological Chem., vol. 255, No. 13, 1980, pp. 6071-6076.
Bizzini et al., Brain Research, 193, 1980, pp. 221-227.
Institut Pasteur
Moezie F. T.
Phillips Delbert R.
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