Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2006-11-21
2006-11-21
Davis, Brian (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S432000
Reexamination Certificate
active
07138543
ABSTRACT:
The present invention relates to new thiolalkyl benzoic acids, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, glaucoma, retinal disorders, and cancer.
REFERENCES:
patent: 3053890 (1962-09-01), Schatter
patent: 5089388 (1992-02-01), Singh et al.
patent: 5204358 (1993-04-01), Young et al.
patent: 5258551 (1993-11-01), Murabayashi et al.
patent: 5314918 (1994-05-01), Frazee et al.
patent: 5409780 (1995-04-01), Schrier et al.
patent: 5453502 (1995-09-01), Aikins et al.
patent: 5998334 (1999-12-01), Murai et al.
patent: 6265609 (2001-07-01), Jackson et al.
patent: 6458775 (2002-10-01), Jackson et al.
patent: 2002/0019430 (2002-02-01), Jackson et al.
patent: WO 94/03835 (1994-02-01), None
patent: WO 98/42661 (1998-10-01), None
patent: WO 00/01668 (2000-01-01), None
patent: WO 2001092274 (2001-05-01), None
patent: WO 01/91738 (2001-12-01), None
patent: WO 01/92273 (2001-12-01), None
patent: WO 01/92274 (2001-12-01), None
Journal of Medicinal Chemistry, (1988) 31 (3) pp. 692-696.
Reed et al., “Nucleophilicities of Selected Ions in Water at 195°C”,Journal of Organic Chemistry, 1993, pp. 6372-6376, vol. 58, No. 23, American Chemical Society, Washington, D.C.
Martin et al., “↑-Amino-thiols Inhibit the Zinc Metallopeptidase Activity of Tetanus Toxin Light Chain”,Journal of Medicinal Chemistry, 1998, pp. 3450-3460, vol. 41, No. 18, American Chemical Society, Washington, D.C.
Barkenbus et al., “The Reaction of Para-Substituted Benzyl Chlorides with Sodium Hydrogen Sulfide”,Journal of the American Chemical Society, Oct. 1927, pp. 2549-2553, vol. 27, No. 10, American Chemical Society, Washington, D.C.
Database Crossfire Beilstein ′Online!, Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main DE; Database accession No. 3215120 (Citation No.) XP-002217097.
Vegh et al., “A New Convenient Method for Preparation of Condensed Aromatic and Heterocyclic Thiolactones,”Synthetic Communications, 1992, pp. 2057-2061, vol. 22, No. 4, Marcel Dekker Inc., Basel, Switzerland.
Salteris, et al., “Ortho-directed lithiation of -omega, -phenoxyalkanethiols and N,N-dimethyl- -omega—phenyoxyalkylamines,” C.A. 131:243360 (1999).
Haj-Yehia, Abdullah, “Preparation of aromatic and heterocyclic nitrato derivatives as vasodilators,” C.A. 129:276593, C.A. 129:275693 (1998).
Ollmann, et al., “Investigation of the inhibition of leukotriene A4 hydrolase,” C.A. 123:160088 (1995).
Arnost, et al., “Thermally developable photosensitive material,” C.A. 121:145198 (1994).
Chauvel et al., “Investigation of the inhibition of leukotriene A4 hydrolase,” C.A. 121:57907 (1994).
Singh, Prithipal, et al., “Salicylate conjugates and their preparation for immunogens and immunoassays,”:C.A. 116:207795 (1992).
Hirai, Hiroyuki, et al., “Heat-developable photographic material,” C.A. 116:48968 (1992).
Frazee, et al., “Leukotriene antagonists,” C.A. 115:49105 (1991).
Young, Robert N., et al., “Preparation of diarlystyrylquinoline diacids as leukotriene antagonists,” C.A. 115:256016 (1991).
Bernstein, Peter R., et al., “Synthesis and pharmacological characterization of a series of leukotriene analogs with antagonist and agonist activities,” C.A. 108:94241 (1988).
Thorpe, Philip E., et al., “New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo,” C.A. 108:87663 (1988).
Asahi chemical Industry Co., Ltd., Japan, “Printing of textiles with sulfur vat dyes,” C.A. 98:18055 (1983).
Portnyagina, V.A., et al., “Synthesis and properties of 1,3-dimercapto derivatives of aromatic carboxylic acids and o-aminophenol,” C.A. 96:68506 (1982).
Staab, Heinz A., et al., “[2.2] (2,7) Pyrenophane as an excimer model: synthesis and spectroscopic properties,” C.A. 92:58489 (1978).
Chan, Edward Y., et al., “Benzothiazepinones, related compounds, and the Smiles rearrangement,” C.A. 92:41909 (1979).
Mizuykova, I.G., et al., “Structure-toxicity relations of some thiol compounds,” C.A. 73:23599 (1970).
Hsieh, Yu-Yuan, et al., “Chemotherapeutic studies on schistosomiasis—(IV) aryl ethers of dimercaptopropanol and their antimonial mercaptides,” C.A. 52:15510b (CAOLD) (1988).
Lysenko, N.M., “Synthesis of certain beta -diothios,” C.A. 61:10583h (CAOLD) (1990).
Schlatter, Maurice J., “Products from HCHO and o-mercaptomethylbenzoic acid,” C.A. 58:3359g (CAOLD) (1962).
Rees, Rees B., et al., “Aminopterin for psoriasis,” C.A. 5320529f (CAOLD) (1959).
Beilstein Reg. No. (BRN): 3237981, 4-mercaptomethyl-benzoic acid, CAS reg. No. 39088-65-8 (2000).
Bernstein, P.R., et al., J. Med. Chem. (1988), 31(3), 692-6.
Chan, E.Y., et al.,Phosphorus and Sulfur, 1979, vol. 7, pp. 41-45.
Staab, H.A., Liebigs Ann. Chem. (1979), (6), 886-98.
Thorpe, P.E., Cancer Res. (1987), 47, 5924-31.
Stoermer Doris
Tsukamoto Takashi
Vitharana Dilrukshi
Arnold & Porter LLP
Chong Suet M.
Davis Brian
Guilford Pharmaceuticals Inc.
LandOfFree
Thiolalkyl benzoic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thiolalkyl benzoic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiolalkyl benzoic acid derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3651420