Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-08-16
2011-08-16
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S521000
Reexamination Certificate
active
07998952
ABSTRACT:
This invention provides compounds of formula I:wherein R1, R2, R3, R4, R5, and R6are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
REFERENCES:
patent: 5827849 (1998-10-01), Himmelsbach et al.
patent: 5854236 (1998-12-01), Albright et al.
patent: 6686352 (2004-02-01), Masciadri et al.
patent: 2003/0083327 (2003-05-01), Davies et al.
patent: 2003/0181439 (2003-09-01), Meijer et al.
patent: 2003/0191143 (2003-10-01), Pitts et al.
patent: 2005/0020830 (2005-01-01), Allen et al.
patent: 2006/0100194 (2006-05-01), Blackburn et al.
patent: 2009/0105213 (2009-04-01), Blackburn et al.
patent: 06 172355 (1994-06-01), None
patent: WO 95/06640 (1995-03-01), None
patent: WO 97/47601 (1997-12-01), None
patent: WO 97/47624 (1997-12-01), None
patent: WO 02/06288 (2002-01-01), None
patent: WO 02/087513 (2002-11-01), None
patent: WO 02/088079 (2002-11-01), None
patent: WO 02/088080 (2002-11-01), None
patent: WO 02/094834 (2002-11-01), None
patent: WO 03/104230 (2003-12-01), None
patent: WO 2004/076424 (2004-09-01), None
patent: WO 2005/007655 (2005-01-01), None
patent: WO 2005/037843 (2005-04-01), None
patent: WO 2005/111039 (2005-11-01), None
patent: WO 2006/041773 (2006-04-01), None
patent: WO 2007/003536 (2007-01-01), None
U.S. Appl. No. 12/903,370, filed Oct. 13, 2010, Blackburn et al., Feb. 17, 2011.
International Search Report and Written Opinion dated Apr. 22, 2010 from International Application No. PCT/US2009/006391, which relates to U.S. Appl. No. 12/631,144, filed Dec. 4, 2009.
International Search Report and Written Opinion dated Jun. 3, 2006 from International Application No. PCT/US2005/035458, which relates to U.S. Appl. No. 11/242,413.
Chetoni, Fabio, et al., “Synthesis of Novel 1-Aryl[1]benzoxepino[5,4-c]pyrazole and [1]Benzoxepino[5,4-d]pyrimidine Derivatives,”Journal of Heterocyclic Chemistry, vol. 30 (Dec. 1993), pp. 1653-1658.
Chen, Wen-Yean, et al., “Synthesis of 7-Phenylpyrimido[5,4-d][1]benzazepin-2-ones (1),”Journal of Heterocyclic Chemistry, vol. 20 (May-Jun. 1983), pp. 663-666.
Kunick, Conrad, et al., “Evaluation and Comparison of 3D-QSAR CoMSIA Models for CDK1, CDK5, and GSK-3 Inhibition by Paullones,”Journal of Medicinal Chemistry, vol. 47, No. 1 (2004), pp. 22-36.
Link, Andreas, et al., “d-Fused [1]Benzazepines with Selective in Vitro Antitumor Activity: Synthesis and Structure-Activity Relationships,”Journal of Medicinal Chemistry. vol. 41, No. 8 (1998), pp. 1299-1305.
Leost, Maryse, et al., “Paullones Are Potent Inhibitors of Glycogen Synthase Kinase-3β and Cyclin-Dependent Kinase 5/p25,”European Journal of Biochemistry, vol. 267, No. 19 (2000), pp. 5983-5994.
Proctor, George R., et al., “Azabenzocycloheptenones. Part 19. Formation of Some Heterocyclic Annelated Compounds from 1,2,3,4-Tetrahydro-1-benzazepine Derivatives,”Journal of the Chemical Society. Perkin Transactions I(1978), pp. 862-870.
Bharathan Indu T.
Duffey Matthew
Elder Amy
Guo Jianping
Li Gang
Kifle Bruck
Millennium Pharmaceuticals Inc.
Millennium Pharmaceuticals Inc.
LandOfFree
Thiolactams and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thiolactams and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiolactams and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2711510