Thiol reactive liposomes

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424 11, 424 38, 424 85, 424 88, 436501, 436532, 436829, B01J 1302, B32B 902

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active

044290080

ABSTRACT:
Liposomes are provided which have a plurality of thiol reactive groups extending outward of the liposomal bilayer. The liposomes form stable covalent bonds with ligands having thiol groups, such as Fab' fragments. Particularly preferred liposomes include maleimide moieties as the thiol reactive groups. The thiol reactive liposomes are usefully employed in agglutination assays, such as blood typing and binding inhibitions, and targeting to specific cells.

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